Publications by authors named "Htet Htwe Htwe"
Lysosomes must maintain the integrity of their limiting membrane to ensure efficient fusion with incoming organelles and degradation of substrates within their lumen. Pancreatic cancer cells upregulate lysosomal biogenesis to enhance nutrient recycling and stress resistance, but it is unknown whether dedicated programmes for maintaining the integrity of the lysosome membrane facilitate pancreatic cancer growth. Using proteomic-based organelle profiling, we identify the Ferlin family plasma membrane repair factor Myoferlin as selectively and highly enriched on the membrane of pancreatic cancer lysosomes.
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- Pancreatic ductal adenocarcinoma (PDA) has different subtypes, with a basal-like variant showing worse prognosis compared to the classical subtype.
- The study reveals that the GLI2 transcription factor is crucial in determining the subtype of PDA, as its increase can transform classical PDA cells into the more aggressive basal-like cells.
- GLI2 activates Osteopontin (OPN), a protein that promotes tumor growth and metastasis, and higher levels of both GLI2 and OPN are linked to reduced survival rates in PDA patients.