Publications by authors named "Hsueh-Ju Lin"
Article Synopsis
- Serum uric acid levels are linked to cardiovascular events and mortality, and the rs2231142 TT genotype is associated with higher uric acid levels but lower risk for coronary artery disease (CAD) in a Taiwanese population.
- A study with 139,508 participants analyzed the effects of the rs2231142 genetic variants on the Framingham Risk Score for Cardiovascular Disease (FRS-CVD) using logistic regression.
- Findings showed that TT genotype carriers exhibited better metabolic health markers despite having the same FRS-CVD score, indicating a reduced cardiovascular risk, especially among non-obese females with hyperuricemia.
Article Synopsis
- Thiopurine methyltransferase (TPMT) is crucial in metabolizing Azathioprine (AZA), and variations in TPMT genes may lead to different side effects like myelosuppression and hepatotoxicity.
- This study focused on the link between TPMT gene variations and hepatotoxicity in Asian patients who had previously used AZA, involving a total of 50 non-normal metabolizer (non-NM) patients and 1000 normal metabolizers (NM).
- Results indicated that non-NM patients had a significantly higher risk of hepatotoxicity, with cumulative incidence rates rising over three years, suggesting that genetic testing for TPMT variants can help tailor safer AZA treatments.
Enterobacter hormaechei, a member of the Enterobacter cloacae complex, has emerged as an important pathogen in healthcare-associated infections. Advancements in phylogenetic analyses and whole-genome sequencing techniques have led to the identification of E. hormaechei in numerous locations worldwide.
View Article and Find Full Text PDFBackground: rs2231142 is an important genetic factor that contributes to the development of gout and hyperuricemia (HUA). Epidemiologic studies have demonstrated that lifestyle risk factors of HUA (e.g.
View Article and Find Full Text PDFBacteriophages and phage-delivered CRISPR-Cas system as antibacterial therapy.
Int J Antimicrob Agents
January 2022
Article Synopsis
- Multidrug-resistant bacterial infections are increasingly threatening human health globally due to the rise of antimicrobial resistance.
- Phage therapy is emerging as a promising solution to fight these MDR bacteria, with numerous successful applications documented.
- The review highlights randomized control trials of phage therapy and illustrates how the CRISPR-Cas system can be effectively delivered via phage vectors to create new antimicrobials.
Background: Familial hypercholesterolemia (FH) has been associated with early coronary artery disease (CAD) and increased risk of atherosclerotic cardiovascular disease. However, the prevalence of FH and its long-term outcomes in a CAD-high-risk cohort, defined as patients with hypercholesteremia who underwent coronary angiography, remains unknown. Besides, studies regarding the impact of genetic variations in FH on long-term cardiovascular (CV) outcomes are scarce.
View Article and Find Full Text PDFGenetic variants and obesity are risk factors for hyperuricemia (HUA). Recent genome-wide association studies have identified rs2231142 as one of the most prominent genetic variants for HUA in an East Asian population. Nevertheless, no large-scale studies have demonstrated any interactive effects between this variant and obesity on serum urate level in Asians.
View Article and Find Full Text PDFFamilial hypercholesterolemia (FH) is a common genetic disorder characterized by a lifelong elevated low-density lipoprotein cholesterol (LDL-C) level. The relationship between FH and ischemic stroke is still controversial. We enrolled ischemic stroke patients prospectively in our neurological ward, and divided them into two groups according to LDL-C levels with a threshold of 130 mg/dl.
View Article and Find Full Text PDFInhibition of Na-K-Cl cotransporter isoform 1 reduces lung injury induced by ischemia-reperfusion.
J Thorac Cardiovasc Surg
January 2017
Objectives: Ischemia-reperfusion acute lung injury is characterized by increased vascular permeability, lung edema, and neutrophil sequestration. Ischemia-reperfusion acute lung injury occurs in lung transplantation and other major surgical procedures. Effective regulation of alveolar fluid balance is critical for pulmonary edema.
View Article and Find Full Text PDFThe ability to maintain optimal intracellular pH (pH(i)) is an essential requirement for all cells. Na⁺-H⁺ exchanger (NHE), a ubiquitously expressed transmembrane protein, has been found widely as a major acid extruder in many different cell types, including human monocytes. We therefore investigated the mechanism of the active pH(i) recovery from intracellular acidosis (induced by NH₄Cl prepulse) using intracellular 2',7'-bis (2-carboxethyl)-5(6)-carboxyl-fluorescein (BCECF) fluorescence in cultured human monocytes.
View Article and Find Full Text PDFObjectives: To investigate mechanisms involved in the regulation of epithelial ion channels and alveolar fluid clearance in hyperoxia-induced lung injury.
Design: Laboratory animal experiments.
Setting: Animal care facility procedure room in a medical center.