Safety, Tolerability, and Preliminary Efficacy of Serplulimab, a Novel Anti-PD-1 Antibody, in Patients with Metastatic or Recurrent Solid Tumors: A Phase I Study.

Background: Serplulimab is a novel, recombinant, humanized, monoclonal, anti-programmed death 1 antibody with a similar or better affinity and pre-clinical antitumor activity than pembrolizumab and nivolumab.

Objective: This phase I, open-label, dose-escalation study evaluated serplulimab in patients with advanced solid tumors. The second interim analysis of the dose-finding phase is reported here.

An interference model for visual and verbal working memory.

Research on working memory (WM) has followed two largely independent traditions: One concerned with memory for sequentially presented lists of discrete items, and the other with short-term maintenance of simultaneously presented arrays of objects with simple, continuously varying features. Here we present a formal model of WM, the interference model (IM), that explains benchmark findings from both traditions: The shape of the error distribution from continuous reproduction of visual features, and how it is affected by memory set size; the effects of serial position for sequentially presented items, the effect of output position, and the intrusion of nontargets as a function of their distance from the target in space and in time. We apply the model to two experiments combining features of popular paradigms from both traditions: Lists of colors (Experiment 1) or of nonwords (Experiment 2) are presented sequentially and tested through selection of the target from a set of candidates, ordered by their similarity.

Efficacy, safety and cost of emicizumab prophylaxis in haemophilia A patients with inhibitors: A nationwide observational study in Taiwan.

Introduction: Emicizumab mimicking the cofactor function of activated factor VIII (FVIII) restores haemostasis.

Methods: This nationwide observational study aimed to retrospectively investigate efficacy, safety, and cost in 1 year before and up to 3 years after emicizumab prophylaxis for haemophilia A (HA) patients with FVIII inhibitors.

Results And Discussion: A total of 39 severe HA patients with a median age of 23.

Cardiac Dose Predicts the Response to Concurrent Chemoradiotherapy in Esophageal Squamous Cell Carcinoma.

Definitive concurrent chemoradiation (CCRT) is the standard treatment for cervical esophageal cancer and non-surgical candidates. Initial treatment response affects survival; however, few validated markers are available for prediction. This study evaluated the clinical variables and chemoradiation parameters associated with treatment response.

Never Gonna Give You Up Even When It Is Suboptimal.

Previous research showed that animals adopt different foraging strategies in different environment settings. However, research on whether humans adapt their foraging strategies to the foraging environment has shown little evidence of a change in strategies. This study aims to investigate whether humans will adapt their foraging strategies when performance differences between strategies are large and why participants may fixate on a single strategy.

TMTC1 promotes invasiveness of ovarian cancer cells through integrins β1 and β4.

Ovarian cancer is the most lethal gynecological malignancy and is characterized by peritoneal disseminated metastasis. Although O-mannosyltransferase TMTC1 is highly expressed by ovarian cancer, its pathophysiological role in ovarian cancer remains unclear. Here, immunohistochemistry showed that TMTC1 was overexpressed in ovarian cancer tissues compared with adjacent normal ovarian tissues, and high TMTC1 expression was associated with poor prognosis in patients with ovarian cancer.

Truncation of GalNAc-type O-glycans Suppresses CD44-mediated Osteoclastogenesis and Bone Metastasis in Breast Cancer.

Unlabelled: The glycoprotein CD44 is a key regulator of malignant behaviors in breast cancer cells. To date, hyaluronic acid (HA)-CD44 signaling pathway has been widely documented in the context of metastatic bone diseases. Core 1 β1,3-galactosyltransferase (C1GALT1) is a critical enzyme responsible for the elongation of O-glycosylation.

A large family of hereditary spherocytosis and a rare case of hereditary elliptocytosis with a novel SPTA1 mutation underdiagnosed in Taiwan: A case report and literature review.

Rationale: Hereditary spherocytosis (HS) has a defect in the vertically connected proteins on the cell membrane of red blood cells (RBC). Hereditary elliptocytosis (HE) has a defect in proteins that connect the cell membrane horizontally. We reported two families of RBC membrane disorders in Taiwanese, one was HS and the other was HE.

Adversarial Patch Attacks on Deep-Learning-Based Face Recognition Systems Using Generative Adversarial Networks.

Deep learning technology has developed rapidly in recent years and has been successfully applied in many fields, including face recognition. Face recognition is used in many scenarios nowadays, including security control systems, access control management, health and safety management, employee attendance monitoring, automatic border control, and face scan payment. However, deep learning models are vulnerable to adversarial attacks conducted by perturbing probe images to generate adversarial examples, or using adversarial patches to generate well-designed perturbations in specific regions of the image.

GALNT2 promotes invasiveness of colorectal cancer cells partly through AXL.

GalNAc-type O-glycosylation and its initiating GalNAc transferases (GALNTs) play crucial roles in a wide range of cellular behaviors. Among 20 GALNT members, GALNT2 is consistently associated with poor survival of patients with colorectal cancer in public databases. However, its clinicopathological significance in colorectal cancer remains unclear.

Oral Squamous Cell Carcinoma Metastasizing to the Heart: A Case Report from Taiwan.

Background: The most common sites for metastasis from head and neck cancers are the lungs, bones, and liver. We present a rare case of squamous cell carcinoma of the buccal mucosa that metastasized to the right ventricle, pericardium, and bilateral lungs.

Methods: A 61-year-old man with oral squamous cell carcinoma (cT4aN2cM0) exhibited mass-like echogenicity adhering to the right ventricular free wall that was accidentally discovered after concurrent chemoradiotherapy.

Antipsychotic Use in Early Pregnancy and the Risk of Maternal and Neonatal Complications.

Objective: To assess the association between antipsychotic use in early pregnancy and the risk of maternal and neonatal metabolic complications.

Methods: We conducted a population-based retrospective cohort study (January 1, 2010, to December 31, 2016) using the Health and Welfare Database in Taiwan. Pregnant women (18 to 49 years of age) were grouped as antipsychotic users (ie, received oral antipsychotic monotherapy during the first 20 weeks of pregnancy) and nonusers.

Congenital factor V deficiency in Taiwan: identification of a novel variant p.Tyr1813 ∗ and two variants specific to East Asians.

Congenital coagulation factor V deficiency (FVD) is a rare, autosomal recessive bleeding disorder. We characterized the clinical presentations, laboratory features, and genetic alterations of Taiwanese patients with FVD. From 1983 to 2010, five women, one man, and one boy diagnosed with FVD were enrolled in this study.

Characterization of congenital factor XII deficiency in Taiwanese patients: identification of one novel and one common mutation.

Background: Factor XII (FXII) deficiency is an interesting condition that causes prolonged activated partial thromboplastin time without bleeding diathesis. FXII may be not important in hemostasis, but still plays roles in thrombosis and inflammation. In order to raise clinical awareness about this condition, we studied patients with severe FXII deficiency and their relatives.

NOVEL-1st: an observational study to assess the safety and efficacy of nilotinib in newly diagnosed patients with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase in Taiwan.

Nilotinib has been approved for the treatment of Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase (Ph CML-CP). However, the real-world evidence of nilotinib in newly diagnosed untreated Ph CML-CP is limited in Taiwan. The NOVEL-1st study was a non-interventional, multi-center study collecting long-term safety and effectiveness data in patients with newly diagnosed and untreated Ph CML-CP receiving nilotinib.

Effects of LED Light Illumination on the Growth, Digestive Enzymes, and Photoacclimation of in Captivity.

is a stony coral valued for its reef-building potential and its unique appearance. Thus, identifying the optimal culture conditions for would enable efficient cultivation and prevent the illegal exploitation of marine resources. Light sources are crucial for the growth of corals because zooxanthellae provide them with basic nutrients through photosynthesis.

An interference model for visual working memory: Applications to the change detection task.

Most studies of visual-working memory employ one of two experimental paradigms: change-detection or continuous-stimulus reproduction. In this study, we extended the Interference Model (IM; Oberauer & Lin, 2017), which was designed for continuous reproduction, to the single-probe change-detection task. In continuous reproduction, participants occasionally report the non-target items instead of the target.

Deep vein thrombosis after major orthopedic surgery in Taiwan: A prospective cross-sectional study and literature review.

Background/purpose: Postoperative venous thromboembolism is an important complication in Taiwan. We prospectively investigated the occurrence of deep vein thrombosis (DVT) after major orthopedic surgery without pharmacologic thromboprophylaxis in a cohort of 120 patients (46 males, 74 females, median age 71 years) at our institute.

Methods: Color duplex compression ultrasonography (CUS) was used to detect DVT before and after the operation, while contrast venography was performed postoperatively for comparison and validation.