The Upstream 1350~1250 Nucleotide Sequences of the Human Gene Contain Critical -Elements Responsible for Upregulating Its Transcription during ER Stress.

encodes an endoribonuclease that overcomes the inhibitory upstream open reading frame (uORF)-trap at 5'-untranslated region (UTR) of the transcript, allowing the downstream coding sequence of be translated during endoplasmic reticulum (ER) stress. However, transcriptional control of remains enigmatic. To address this, we cloned an upstream 2.