Re-irradiation combined with bevacizumab for recurrent glioblastoma beyond bevacizumab failure: survival outcomes and prognostic factors.

The combination of re-irradiation and bevacizumab has emerged as a potential therapeutic strategy for patients experiencing their first glioblastoma multiforme (GBM) recurrence. This study aims to assess the effectiveness of the re-irradiation and bevacizumab combination in treating second-progression GBM patients who are resistant to bevacizumab monotherapy. This retrospective study enrolled 64 patients who developed a second progression after single-agent bevacizumab therapy.

Civilian gunshot wounds to the brain.

Background: Civilian gunshot wounds to the brain are relatively rare, and a much-neglected subject in Taiwan. We present our experience with 16 patients who sustained gunshot wounds to the brain, and then identify factors determining the respective outcomes.

Methods: From 1988-2002, data from 16 patients with civilian gunshot wounds to the brain, who were treated at Taichung Veterans General Hospital, were retrospectively reviewed.