Publications by authors named "Hsu P Chiang"
Article Synopsis
- Sonothrombolysis, which involves using high mechanical index impulses during an intravenous microbubble infusion, can improve myocardial perfusion in patients with acute ST segment elevation myocardial infarction, but its impact on diastolic dysfunction and left atrial mechanics was assessed for the first time.
- In a study with 100 patients split into two groups (therapy plus PCI vs. PCI only), those receiving sonothrombolysis showed less worsening of diastolic dysfunction and better left atrial mechanics over a follow-up period.
- Overall, the therapy group experienced significantly improved left atrial global longitudinal strain and were less likely to undergo left atrial remodeling compared to the control group, suggesting that sonothrombolysis may offer protective benefits
Introduction: Clopidogrel has been demonstrated to be effective in improving coronary microcirculation (CM) among patients with ST-elevation myocardial infarction (STEMI) treated with fibrinolytics. Ticagrelor is a more potent adenosine diphosphate (ADP) receptor blocker proven to be superior to clopidogrel among patients with acute coronary syndromes. The present study aimed to compare the effects of ticagrelor and clopidogrel on CM in patients with STEMI treated with fibrinolytics.
View Article and Find Full Text PDFCorrection to: Usefulness of speckle tracking echocardiography and biomarkers for detecting acute cellular rejection after heart transplantation.
Cardiovasc Ultrasound
January 2021
Background: Acute cellular rejection (ACR) is a major complication after heart transplantation. Endomyocardial biopsy (EMB) remains the gold standard for its diagnosis, but it has concerning complications. We evaluated the usefulness of speckle tracking echocardiography (STE) and biomarkers for detecting ACR after heart transplantation.
View Article and Find Full Text PDFBackground: It has recently been demonstrated that high-energy diagnostic transthoracic ultrasound and intravenous microbubbles dissolve thrombi (sonothrombolysis) and increase angiographic recanalization rates in patients with ST-segment-elevation myocardial infarction. We aimed to study the effect of sonothrombolysis on the myocardial dynamics and infarct size obtained by real-time myocardial perfusion echocardiography and their value in preventing left ventricular remodeling.
Methods: One hundred patients with ST-segment-elevation myocardial infarction were randomized to therapy (50 patients treated with sonothrombolysis and percutaneous coronary intervention) or control (50 patients treated with percutaneous coronary intervention only).
Article Synopsis
- Cardiac shock-wave therapy (CSWT) is an emerging treatment for patients with refractory angina, showing immediate and long-term benefits in heart blood flow.
- In a study involving 15 patients who received nine CSWT sessions, treated ischemic heart segments showed a significant increase in myocardial blood flow reserve (MBFR) six months post-treatment.
- Patients also reported improved angina symptoms, with notable decreases in Canadian Cardiovascular Society scores and increases in Seattle Angina Questionnaire scores, all without major cardiovascular events during follow-up.
Article Synopsis
- Preclinical studies indicate that high mechanical index (MI) ultrasound impulses can enhance blood flow during treatment for ST-segment elevation myocardial infarction (STEMI).
- A clinical trial involving 100 patients tested sonothrombolysis combined with standard percutaneous coronary intervention (PCI) against PCI alone to evaluate its effects on heart function and recovery.
- Results showed that patients receiving sonothrombolysis had significantly better outcomes in terms of heart function improvement, reduced infarct size, and higher rates of blood flow restoration compared to those who only underwent PCI.