Feruloylacetone and Its Analog Demethoxyferuloylacetone Mitigate Obesity-Related Muscle Atrophy and Insulin Resistance in Mice.

Obesity-induced muscle alterations, such as inflammation, metabolic dysregulation, and myosteatosis, lead to a decline in muscle mass and function, often resulting in sarcopenic obesity. Currently, there are no definitive treatments for sarcopenic obesity beyond lifestyle changes and dietary supplementation. Feruloylacetone (FER), a thermal degradation product of curcumin, and its analog demethoxyferuloylacetone (DFER), derived from the thermal degradation of bisdemethoxycurcumin, have shown potential antiobesity effects in previous studies.

Functionalization of Pyridines at the C4 Position via Metalation and Capture.

The functionalization of pyridines at positions remote to the N-atom remains an outstanding problem in organic synthesis. The inherent challenges associated with overriding the influence of the embedded N-atom within pyridines was overcome using n-butylsodium, which provided an avenue to deprotonate and functionalize the C4-position over traditionally observed addition products that are formed with organolithium bases. In this work, we show that freshly generated 4-sodiopyrdines could undergo transition metal free alkylation reactions directly with a variety of primary alkyl halides bearing diverse functional groups.

Circulating CD3CD8 T Lymphocytes as Indicators of Disease Status in Patients With Early Breast Cancer.

Circulating CD3CD8 cell levels were lower in breast cancer patients, elevated posttreatment, and subsequently declining upon recurrence. Elevated plasma chemokine (C-C motif) ligand 2 (CCL2) levels distinguished patients with breast cancer from healthy controls. In summary, circulating CD3CD8 CTL and plasma CCL2 levels emerged as promising dual-purpose biomarkers and therapeutic targets in breast cancer management.

High-speed FSO-5G wireless communication system with enhanced loss compensation using high-power EDFA.

In this paper, we demonstrated a novel bidirectional high-speed transmission system integrating a free-space optical (FSO) communication with a 5G wireless link, utilizing a high-power erbium-doped fibre amplifier (EDFA) for enhanced loss compensation. The system supports downlink rates of 1-Gb/s/4.5-GHz and 10-Gb/s at 24-GHz and 39-GHz, and an uplink rate of 10-Gb/s/28-GHz.

Immune checkpoint inhibitor-induced severe epidermal necrolysis mediated by macrophage-derived CXCL10 and abated by TNF blockade.

Immune checkpoint inhibitors (ICI) represent new anticancer agents and have been used worldwide. However, ICI can potentially induce life-threatening severe cutaneous adverse reaction (SCAR), such as Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), hindering continuous ICI therapy. We examine 6 cohorts including 25 ICI-induced SJS/TEN patients and conduct single-cell RNA sequencing (scRNA-seq) analysis, which shows overexpression of macrophage-derived CXCL10 that recruits CXCR3 cytotoxic T lymphocytes (CTL) in blister cells from ICI-SJS/TEN skin lesions.

Developing a novel transitional care model for older emergency department patients and exploring the target population in Taiwan.

Aim: Transitional care in the emergency department (ED) has the potential to improve outcomes for older patients, but the specific population benefits from it and impact in Taiwan remain unclear. Therefore, we conducted this study.

Methods: An interdisciplinary team comprising emergency physicians, dedicated transitional care nurse (TCN), nurse practitioners, nurses, geriatricians, and social workers was established at a tertiary medical center.

Phase 1b/2 study of orally administered pexidartinib in combination with radiation therapy and temozolomide in patients with newly diagnosed glioblastoma.

Background: Glioblastoma (GBM) has a median survival of <2 years. Pexidartinib (PLX3397) is a small-molecule inhibitor of CSF1R, KIT, and oncogenic FTL3, which are implicated in GBM treatment resistance. Results from glioma models indicate that combining radiation therapy (RT) and pexidartinib reduces radiation resistance.

Younger age as an independent factor for second primary head and neck cancer in esophageal squamous cell carcinoma patients after curative esophagectomy: A two-center retrospective study.

Background: Postoperative survival of esophageal cancer patients has improved with advances in technology and treatment modalities. However, squamous cell carcinoma (SCC) often affects the esophagus together with the head and neck regions, with second primary head and neck cancer (SPHNC) adversely influencing the patients' quality of life. Therefore, patients with esophageal squamous cell carcinoma (ESCC) should be carefully followed up postoperatively.

Iron triggers PI4P5K proteostasis and Arf-mediated cell membrane trafficking to regulate PIP signaling crucial for multiple pathogenic activities of the parasitic protozoan .

is the etiologic agent of trichomoniasis, one of the most common non-viral sexually transmitted infections globally. Our previous work reported the role of phosphatidylinositol 4,5-bisphosphates (PIP) signaling in the actin-dependent pathogenicity of . This study further demonstrated that iron transiently regulated phosphatidylinositol-4-phosphate 5-kinase (PI4P5K) proteostasis and its complex formation with an active ADP ribosylation factor Arf220, facilitating co-trafficking to the plasma membrane, crucial for PIP production.

Optimally Miscible Polymer Bulk-Heterojunction-Particles for Nonsurfactant Photocatalytic Hydrogen Evolution.

Mini-emulsion and nanoprecipitation techniques relied on large amounts of surfactants, and unresolved miscibility issues of heterojunction materials limited their efficiency and applicability in the past. Through our molecular design and developed surfactant-free precipitation method, we successfully fabricated the best miscible bulk-heterojunction-particles (BHJP) ever achieved, using donor () and acceptor () polymers. The structural similarity ensures optimal miscibility, as supported by the interaction parameter of the / blend is positioned very close to the binodal curve.

Regulating Strain and Suppressing Defect States Through Polymer Ionization and Chemical Chelation for Efficient Inverted Flexible Perovskite Solar Cells.

Flexible perovskite solar cells (FPSCs) have great promise for applications in wearable technology and space photovoltaics. However, the unpredictable crystallization of perovskite on flexible substrates results in significantly lower efficiency and mechanical durability than industry standards. A strategy is investigated employing the polymer electrolyte poly(allylamine hydrochloride) (PAH) to regulate crystallization and passivate defect states in perovskite films on flexible substrates.

Suppressing Interface Defects in Perovskite Solar Cells via Introducing a Plant-Derived Ergothioneine Self-Assembled Monolayer.

Perovskite solar cells are among the most promising renewable energy devices, and enhancing their stability is crucial for commercialization. This research presents the use of L-Ergothioneine (L-EGT) as a passivation material in perovskite solar cells, strategically placed between the electron transport layer and the perovskite absorber layer to mitigate defect states at the heterojunction interface. Surface analysis reveals that introducing L-EGT passivation material significantly improves the quality of the perovskite film.

The genomic and clinical consequences of replacing procarbazine with dacarbazine in escalated BEACOPP for Hodgkin lymphoma: a retrospective, observational study.

Background: Procarbazine-containing chemotherapy regimens are associated with cytopenias and infertility, suggesting stem-cell toxicity. When treating Hodgkin lymphoma, procarbazine in escalated-dose bleomycin-etoposide-doxorubicin-cyclophosphamide-vincristine-procarbazine-prednisolone (eBEACOPP) is increasingly replaced with dacarbazine (eBEACOPDac) to reduce toxicity. We aimed to investigate the impact of this drug substitution on the mutation burden in stem cells, patient survival, and toxicity.

The effectiveness of foam rolling with and without vibration and static stretching on range of motion, muscle strength and proprioception of the ankle joint in adults with chronic ankle instability.

Background: People with chronic ankle instability (CAI) have insufficient ankle dorsiflexion range of motion (DFROM) and decreases proprioception and muscle strength. Foam roller with and without vibration as a warm-up intervention may have benefits for healthy populations, but the effect on applied to injured individuals is still lacking, especially in CAI. Therefore, we aimed to compare the acute effects of three warm-up interventions, including vibration foam rolling (VR), foam rolling (FR), and static stretching (SS) in adults with CAI.

Prognostic significance of perioperative circulating CD56 NK cell and recovery of NK cell activity in patients with colorectal cancer undergoing radical surgery.

Introduction: Natural killer (NK) cell activity (NKA) is downregulated in patients with colorectal cancer (CRC), and its dysfunction is possibly associated with increased risk of recurrence. However, its role in prognosis of CRC remains unclear. Prior research has shown that surgical stress can suppress NKA.

Effect of Electronic Moxibustion in Patients with IDH: A Randomized Crossover Pilot Study.

Objective: Intradialytic hypotension (IDH), a common complication of hemodialysis (HD), is associated with increased cardiovascular risk, morbidity, and mortality. Fatigue is one of the most frequent symptoms of IDH, and deteriorates the quality of life of patients. This study aimed to evaluate the efficacy and safety of electronic moxibustion for improving IDH and its associated symptoms.

Salinomycin attenuates kidney fibrosis and inflammation in mice with unilateral ureteral obstruction.

Renal fibrosis is a crucial pathological feature in chronic kidney disease (CKD), resulting in the gradual decline of renal function. Salinomycin is an antibiotic discovered from Streptomyces albus that also regulates the fates of cells. However, its potential in kidney fibrosis remains elusive.

Neurological Evidence of Diverse Self-Help Breathing Training With Virtual Reality and Biofeedback Assistance: Extensive Exploration Study of Electroencephalography Markers.

Background: Recent advancements in virtual reality (VR) and biofeedback (BF) technologies have opened new avenues for breathing training. Breathing training has been suggested as an effective means for mental disorders, but it is difficult to master the technique at the beginning. VR-BF technologies address the problem of breathing, and visualizing breathing may facilitate the learning of breathing training.

HYALURONIC ACID INJECTION MAY BE EFFECTIVE FOR RECONSTRUCTION OF MILD TO MODERATE LOSS OF INTERDENTAL PAPILLA IN ADULT PATIENTS IN THE SHORT TERM.

Article Title And Bibliographic Information: The use of hyaluronic acid injection for treatment of black triangle and reconstruction of lost interdental papilla in anterior teeth: a systematic review. ACTA ODONTOLOGICA SCANDINAVICA 2024; VOL. 83: 371-391.