Three cases of advanced seminoma and Down's syndrome: a possible association.

This is a report of three cases of classic seminoma in Down's syndrome patients treated at our institution. Review of literature shows an observation of increased occurrence of testicular cancer in patients with DS, however, with no definitive association documented. A brief discussion of the possible pathogenesis is presented.

Comparative treatment planning between proton and X-ray therapy in pancreatic cancer.

With the utilization of new biologic agents and experimental chemotherapy in the treatment of pancreatic cancer, the issue of local-regional control will become increasingly important. This study was undertaken to determine the feasibility of dose escalation using proton therapy, as compared to conventional 3-dimensional conformal radiation, by minimizing the dose to normal tissues. The photon treatment plans of 4 patients with unresectable pancreatic cancer treated on a biologic therapy trial were utilized.