Publications by authors named "Hsiu-Yi Hung"
Pharmaceutics
December 2021
Article Synopsis
- Traumatic brain injury (TBI), especially mild TBI in juveniles (mTBI-J), can lead to long-term effects such as depression and other mental disorders, as studied in young male rats.
- While physical brain damage was minimal, mTBI-J subjects displayed significant depression-like behaviors, indicated by increased immobility in the forced swimming test and decreased sucrose preference.
- The study found reduced levels of brain-derived neurotrophic factor (BDNF) in the hippocampus of mTBI-J rats, suggesting a link between this protein and the observed behavioral changes, with potential therapeutic effects noted from a TrkB agonist treatment.
