Transcriptional regulation of human eosinophil RNases by an evolutionary- conserved sequence motif in primate genome.

Background: Human eosinophil-derived neurotoxin (edn) and eosinophil cationic protein (ecp) are members of a subfamily of primate ribonuclease (rnase) genes. Although they are generated by gene duplication event, distinct edn and ecp expression profile in various tissues have been reported.

Results: In this study, we obtained the upstream promoter sequences of several representative primate eosinophil rnases.