Publications by authors named "Hsiu-Huang Wang"
Article Synopsis
- The study investigates how excessive consumption of simple sugars negatively affects bone health, particularly during adolescence and early adulthood, which is critical for preventing osteoporosis later in life.
- Researchers performed bioinformatics analyses and conducted experiments on mesenchymal stromal cells (MSCs) to understand the mechanisms behind this link, focusing on mitochondrial function and differentiation into bone-forming cells.
- Findings show that high glucose conditions harm MSC function by depleting a key coenzyme (NAD), leading to a decrease in bone formation and an increase in fat cell formation; however, supplementing with NAD can quickly reverse these effects.
