Publications by authors named "Hsing-Lung Lai"
Effect of melanin produced by a recombinant Escherichia coli on antibacterial activity of antibiotics.
J Microbiol Immunol Infect
October 2005
Article Synopsis
- A recombinant plasmid, pYL-1, was created to express a tyrosinase gene in E. coli, leading to the production of bacterial melanin through a straightforward isolation and purification process.
- Melanins from bacterial sources and chemical synthesis showed increased UV absorption in the 200-400 nm range, whereas plant and animal-derived melanins exhibited a notable peak at 280 nm, suggesting differences in their composition.
- The presence of bacterial melanin reduced the effectiveness of certain antibiotics on E. coli, indicating a possible interaction between melanin and the antibiotics, though the exact mechanism of this interaction is still unknown.