Tissue-resident macrophages (TRMs) are heterogeneous cell populations found throughout the body. Depending on their location, they perform diverse functions maintaining tissue homeostasis and providing immune surveillance. To survive and function within, TRMs adapt metabolically to the distinct microenvironments.
View Article and Find Full Text PDFThe death receptor Fas can induce cell death through the extrinsic pathway of apoptosis in a variety of cells, including developing thymocytes. Although Fas-induced cell death has been researched and modeled extensively, most of the studies have been done because of the lethality of Fas triggering . Thus, little is known about the time line of this type of cell death , specifically, how does the presence of macrophages and pro-survival cytokines affect apoptosis progression.
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