The Care Needs, Preferences, and Coping Strategies of Young Stroke Survivors: A Qualitative Study.

Background: Stroke incidence is rising among younger populations, who often face long-term disabilities. Understanding their care needs, preferences, and coping strategies is essential for recovery.

Objective: The objective of this study -was to explore young stroke survivors' care needs, preferences, and coping strategies within 6 months poststroke.

Potato protein hydrolysate (PPH902) exerts anti-lipogenesis and lipolysis-promoting effect by inhibiting adipogenesis in 3T3-L1 adipocytes.

Obesity is linked to cardiovascular disease, cerebrovascular disease, diabetes, and dyslipidemia, lowering quality of life, work productivity, and healthcare expenditures. The aim of this present study is to investigate the mechanism of potato protein (PP) post-treatment in regulating lipogenesis and lipolysis in 3T3-L1 adipocytes. 9% PP hydrolysed for 2 h (PPH902) shows high yield and better activity; thus, PPH902 was used in all other experiments.

Mortality Outcome Associated with Specific , , and Hot-Spot Mutations in Metastatic Colorectal Cancer Patients: A Retrospective Cohort Study.

The prognostic value of specific hot-spot mutations within , , and genes in metastatic colorectal cancer (mCRC) genes remains debatable. This study explores whether certain , , and mutations are associated with the risk of all-cause mortality in mCRC. We retrospectively analyzed records of 494 patients with mCRC treated at the University of Texas Medical Branch between January 2016 and July 2023.

Psoriasis Risk Is Lower in Type 2 Diabetes Patients Using Dipeptidyl Peptidase-4 Inhibitors or Thiazolidinediones Compared to Sulfonylureas.

The risk of psoriasis in diabetic patients has rarely been explored. This study aims to compare the risk of incident psoriasis in patients with Type 2 diabetes (T2D) who initiate dipeptidyl peptidase-4 inhibitors (DPP-4is) or thiazolidinediones (TZDs) with those who initiate sulfonylureas, the most common second-line glucose-lowering therapy, in addition to metformin monotherapy. This sequential, propensity-score-matched, new-user comparative effectiveness study utilized a target trial emulation framework.

Morphological differences between residual childhood hip dysplasia with previous osteotomy and adolescent-onset hip dysplasia.

Background: Hip dysplasia (HD) at skeletal maturity can result from residual developmental dysplasia of the hip (DDH) treated in childhood or from primary adolescent-onset HD (AOHD). This study aims to compare the pathomorphology of these two HD subtypes with that of a normal control group.

Methods: This retrospective study reviewed patients who underwent periacetabular osteotomy for symptomatic HD between 2013 and 2020.

Phosphorylation-Induced Self-Coacervation versus RNA-Assisted Complex Coacervation of Tau Proteins.

In this study, the role of phosphorylation in the liquid-liquid phase separation (LLPS) of tau, the underlying driving forces, and the potential implications of this separation on protein conformation and subsequent protein aggregation were investigated. We compared in vivo-produced phosphorylated tau (p-tau) and nonphosphorylated tau under different coacervation conditions without adding crowding agents. Our findings revealed that spontaneous phase separation occurs exclusively in p-tau, triggered by a temperature shift from 4 °C to room temperature, and is driven by electrostatic and hydrophobic interactions.

5-Methoxytryptophan Attenuates Oxidative Stress-Induced Downregulation of PINK1 and Mitigates Mitochondrial Damage and Apoptosis in Cardiac Myocytes.

Mitochondrial dysfunction is a hallmark in the pathogenesis of various cardiovascular diseases. 5-Methoxytryptophan (5-MTP), an intrinsic amino acid metabolite, exerts cardioprotective effects potentially through the preservation of mitochondrial integrity. This study investigates the mechanisms and contexts in which 5-MTP positively impacts mitochondrial function using cultured human ventricular cardiomyocytes (HCMs) and HL-1 cardiac cells subjected to oxidative stress (OS).

Breast neurotization along with breast reconstruction after nipple sparing mastectomy enhances quality of life and reduces denervation symptoms in patient reported outcome: a prospective cohort study.

Objective: Persistent postoperative sensory loss significantly limits breast reconstruction following mastectomy. In addition, the absence of sensation profoundly impacts patients' physical well-being and overall quality of life. New surgical techniques involving nerve autograft intercostal nerve elongation have been introduced to neurotize reconstructed breasts.

Relationship and Determinants of Breastfeeding Self-Efficacy Among Postpartum Mothers and Fathers in Malawi: A Cross-Sectional Study.

Background: Breastfeeding self-efficacy among both mothers and fathers is critical in enhancing exclusive breastfeeding rates. However, the interrelationship between maternal and paternal breastfeeding self-efficacy and their determinants remains unknown.

Research Aims: We aimed to (a) investigate the relationship between breastfeeding self-efficacy scores postpartum for mothers and fathers; (b) explore factors associated with breastfeeding self-efficacy in this group; and (c) examine determinants of combined self-efficacy scores among breastfeeding parents in Malawi.

Development and validation of the sarcopenia composite index: A comprehensive approach for assessing sarcopenia in the ageing population.

Introduction: The diagnosis of sarcopenia relies on key indicators such as handgrip strength, walking speed and muscle mass. Developing a composite index that integrates these measures could enhance clinical evaluation in older adults. This study aimed to standardise and combine these metrics to establish a z score for the sarcopenia composite index (ZoSCI) tailored for the ageing population.

Clinical outcome analysis of different first‑ and second‑generation EGFR‑tyrosine kinase inhibitors in untreated patients with EGFR‑mutated non‑small cell lung cancer with baseline brain metastasis.

Currently, the clinical outcomes of patients with epidermal growth factor receptor ()-mutated non-small cell lung cancer (NSCLC) with baseline brain metastasis receiving first- and second-generation EGFR-tyrosine kinase inhibitors (TKIs) are not clear. The present study aimed to assess the clinical outcomes of patients with EGFR-mutated NSCLC with baseline brain metastasis who received first-line first- and second-generation EGFR-TKIs. In the present study, a retrospective analysis of clinical charts was performed to investigate first- and second-generation EGFR-TKIs in patients with -mutated NSCLC with baseline brain metastasis.

Drivers of Job Loss Among Chinese Breast Cancer Survivors: A Qualitative Analysis.

Purpose: This study aimed to understand the reasons for the high risk of job loss previously identified among foreign-born Chinese breast cancer survivors in the United States Qualitative interviews were conducted to explore challenges leading to job loss during/after treatment and to help identify potential interventions to promote job retention and re-employment.

Patients And Methods: The research team conducted semi-structured interviews with foreign-born Chinese breast cancer survivors in New York City. A total of 12 participants, previously enrolled in the Breast Cancer and the Workforce study, were interviewed between February and November 2018.

The Association of Sleep Quality and Internet Addiction With Health Status in Hospital Nurses.

Aim: The aims of this study were to explore the correlation of sleep quality and Internet addiction (IA) with the health status of hospital nurses and to investigate whether sleep quality is a mediator in the influence of IA on the health of the nurses.

Background: Excessive Internet use is a public health concern. However, few researchers have investigated the interrelationship of the IA, sleep quality, and health status of hospital nurses.

Dopamine D1 receptor agonist alleviates post-weaning isolation-induced neuroinflammation and depression-like behaviors in female mice.

Background: Major depressive disorder is a significant global cause of disability, particularly among adolescents. The dopamine system and nearby neuroinflammation, crucial for regulating mood and processing rewards, are central to the frontostriatal circuit, which is linked to depression. This study aimed to investigate the effect of post-weaning isolation (PWI) on depression in adolescent mice, with a focus on exploring the involvement of microglia and dopamine D1 receptor (D1R) in the frontostriatal circuit due to their known links with mood disorders.

Gender norms and sexual violence among South African adolescents: discrepancies between personal attitudes and perceived peer norms.

Social norms, particularly those pertaining to gender equity, can shape attitudes and behaviors that contribute to adolescent sexual violence (SV). This study examines personal attitudes and perceived peer norms regarding gender equity and associations with perpetration of SV among 100 South Africans aged 13-17 in 2019. We assessed: (1) sexual activity and SV behaviors and (2) personal attitudes and perceived peer norms around gender equity.

Provider, staff, and parent perspectives on the feasibility, utility, and implementation of the Family Health Scale in primary care pediatrics.

Introduction: Improving child health involves focusing on family capacities and resources, including family health. This study aimed to assess (a) current practices for collecting family information in pediatric primary care settings, and (b) the feasibility, acceptability, and utility of a validated Family Health Scale-Short Form (FHS-SF) to screen for family health from clinic staff and parent perspectives.

Method: We piloted the FHS-SF in two urban pediatric clinics in 2022.

The skeletal abnormalities and their clinical challenges in -associated syndrome.

-associated syndrome (SAS) is an autosomal dominant genetic disorder caused by pathogenic variations in the special AT-rich sequence-binding protein 2 () gene. In addition to neurodevelopmental and craniofacial defects, over 90% of patients with SAS manifest biochemical and/or radiographic skeletal abnormalities, and around one-third of patients report clinical and/or radiographic fractures. SATB2 protein is a potent transcription factor that promotes osteoblast differentiation and maturation; loss-of-function pathogenic variations of the gene result in a wide spectrum of skeletal abnormalities ranging from gross skeletal anomalies to abnormal bone turnover markers, low BMD, and recurrent fractures.

Comparison between Different Configurations of Reference Electrodes for an Extended-Gate Field-Effect Transistor pH Sensor.

This study investigates the performance and stability of extended-gate field-effect transistor (EGFET) pH sensors with three different reference electrode configurations: conventional external Ag/AgCl, external gold (Au), and integrated Au electrodes. The goal is to identify an optimal reference electrode configuration for enhancing the portability and manufacturability of EGFET pH sensors, which are crucial in medical, agricultural, and environmental applications. Results showed that the integrated Au electrode exhibits superior stability and comparable sensitivity to those of Ag/AgCl and external Au electrodes.

DeepPath: Overcoming data scarcity for protein transition pathway prediction using physics-based deep learning.

The structural dynamics of proteins play a crucial role in their function, yet most experimental and deep learning methods produce only static models. While molecular dynamics (MD) simulations provide atomistic insight into conformational transitions, they remain computationally prohibitive, particularly for large-scale motions. Here, we introduce DeepPath, a deep-learning-based framework that rapidly generates physically realistic transition pathways between known protein states.

A survey of general dentists on the involvement of endodontists in restorative procedures.

Background: The authors investigated, via a web-based survey, the perceptions of general dentists in the United States regarding endodontists restoring endodontically treated teeth (ETT).

Methods: A 15-question survey was distributed to American Dental Association members. Participants were asked to rate their comfort with various scenarios.

IL-19 as a promising theranostic target to reprogram the glioblastoma immunosuppressive microenvironment.

Background: Glioblastoma multiforme (GBM) is an aggressive brain tumor with chemoresistant, immunosuppressive, and invasive properties. Despite standard therapies, including surgery, radiotherapy, and temozolomide (TMZ) chemotherapy, tumors inevitably recur in the peritumoral region. Targeting GBM-mediated immunosuppressive and invasive properties is a promising strategy to improve clinical outcomes.

Metabolomic analysis of methane-reducing seaweed Asparagopsis taxiformis for sustainable production in Taiwan.

This study employed a combined approach of untargeted UHPLC-HRMS and targeted GC-MS analyses to investigate the effects of different cultivation media on the growth and bromoform production of Asparagopsis taxiformis tetrasporophytes. Growth performance and metabolic profiles were analyzed under various nutrient conditions, including PES, F/2, Walne, and a control medium. Significant variations in growth rates and metabolic compositions were observed across the media.