Publications by authors named "Hsin-Kuang Chen"
Twnbiome: a public database of the healthy Taiwanese gut microbiome.
BMC Bioinformatics
December 2023
Article Synopsis
- Recent advancements in next generation sequencing (NGS) technology have made studying bacterial genomes in the environment more affordable and effective, allowing for the identification of previously unknown microbiome species.
- An efficient NGS data analysis pipeline needs to combine various bioinformatics tools, which can be complex and resource-intensive, presenting challenges for biologists and clinicians.
- Twnbiome, a public gut microbiome database developed from healthy Taiwanese subjects, provides an interactive and user-friendly platform for microbiota research, enabling easy data analysis and customizable results for users without a bioinformatics background.
Two strains of identified from different experiments are proposed to represent new species. Strain WLa1L2M3 was isolated from the digestive tract of an beetle larva. Strain 09-1422 was isolated from a cage housing the stick insect .
View Article and Find Full Text PDFsp. nov., isolated from the gut of a millipede () from a coconut tree.
Int J Syst Evol Microbiol
October 2021
During an investigation of microbes associated with arthropods living in decaying coconut trees, a isolate, Milli4, was cultured from the digestive tract of the common Asian millipede, . Sequence analysis of 16S rRNA and genes found that Milli4 was closely related but not identical to Esp-1, B13 and CCA1. Whole genome sequencing suggested that this isolate represents a new species, with average nucleotide identity (OrthoANIu) values of around 83.
View Article and Find Full Text PDFSemaphorin 6A (SEMA6A), a membrane-bound protein, is downregulated in lung cancer tissue compared to its adjacent normal tissue. However, the functions of SEMA6A in lung cancer cells are still unclear. In the present study, full length SEMA6A and various truncations were transfected into lung cancer cells to investigate the role of the different domains of SEMA6A in cell proliferation and survival, apoptosis, and in vivo tumor growth.
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