Publications by authors named "Hsin-Jou Lee"
The field of therapeutic peptides is experiencing a surge, fueled by their advantageous features. These include predictable metabolism, enhanced safety profile, high selectivity, and reduced off-target effects compared with small-molecule drugs. Despite progress in addressing limitations associated with peptide drugs, a significant bottleneck remains: the absence of a large-scale in silico screening method for a given protein target structure.
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- Reactive oxygen species (ROS) and oxidative stress contribute to diabetic nephropathy (DN), and hydralazine, an antihypertensive drug, may help by inhibiting xanthine oxidase (XO) and reducing uric acid levels in experimental models.
- In studies, hydralazine was shown to downregulate inflammatory pathways and reduce oxidative stress in kidney cells exposed to high glucose, leading to less cell death and improved kidney function in diabetic mice.
- The drug not only inhibited XO and NADPH oxidase but also activated protective pathways (Nrf2/HO-1), indicating its potential for comprehensive management of DN through antioxidation and anti-inflammatory actions.