Low Molecular Weight Fucoidan Prevents Radiation-Induced Fibrosis and Secondary Tumors in a Zebrafish Model.

Radiotherapy often causes unwanted side effects such as radiation-induced fibrosis and second malignancies. Fucoidan, a sulfated polysaccharide extracted from brown seaweed, has many biological effects including anti-inflammation and anti-tumor. In the present study, we investigated the radioprotective effect of Oligo-Fucoidan (OF) using a zebrafish animal model.

Transcriptomically Revealed Oligo-Fucoidan Enhances the Immune System and Protects Hepatocytes via the ASGPR/STAT3/HNF4A Axis.

Oligo-fucoidan, a sulfated polysaccharide extracted from brown seaweed, exhibits anti-inflammatory and anti-tumor effects. However, the knowledge concerning the detailed mechanism of oligo-fucoidan on liver cells is obscure. In this study, we investigate the effect of oligo-fucoidan in normal hepatocytes by transcriptomic analysis.

In-phantom neutron dose measurement using Gafchromic film dosimeter for QA of BNCT beams.

In order to improve the quality assurance (QA) procedure for beams of boron neutron capture therapy (BNCT), this study introduced using the Gafchromic film dosimeter for neutron dose measurement of BNCT beams. The crucial part of this study was investigating an approach to employ the Gafchromic film dosimeter placed inside a PMMA phantom irradiated by a BNCT beam. The spatial distribution of neutron dose of the film was determined using measurements and Monte Carlo calculations.

An empirical research on relationships between subjective judgement, technology acceptance tendency and knowledge transfer.

The purpose of this study was to explore the relationships among employees' usage intention pertaining to mobile information devices, focusing on subjective judgement, technology acceptance tendency, information sharing behavior and information transfer. A research model was established to verify several hypotheses. The research model based on integrated concepts of knowledge management and technology acceptance modeling.

Exploring key factors in online shopping with a hybrid model.

Introduction: Nowadays, the web increasingly influences retail sales. An in-depth analysis of consumer decision-making in the context of e-business has become an important issue for internet vendors. However, factors affecting e-business are complicated and intertwined.

Computational study of room scattering influence in the THOR BNCT treatment room.

BNCT dosimetry has often employed heavy Monte Carlo calculations for the beam characterization and the dose determination. However, these calculations commonly ignored the scattering influence between the radiations and the room structure materials in order to facilitate the calculation speed. The aim of this article attempts to explore how the room scattering affects the physical quantities such as the capture reaction rate and the gamma-ray dose rate under in-phantom and free-air conditions in the THOR BNCT treatment room.

Neutron response of GafChromic® EBT2 film.

Neutron and gamma-ray mixed field dosimetry remains one of the most challenging topics in radiation dosimetry studies. However, the requirement for accurate mixed field dosimetry is increasing because of the considerable interest in high-energy radiotherapy machines, medical ion beams and BNCT epithermal neutron beams. Therefore, this study investigated the GafChromic® EBT2 film.

Macro- and microdistributions of boron drug for boron neutron capture therapy in an animal model.

Background: The boron concentration (BC) in the blood, rather than in normal tissue, is often used as the reference to calculate the BC in tumor for boron neutron capture therapy (BNCT). The aims of this study were to justify whether BC in the blood is equal to that of normal tissue, and to verify the macro- and microdistributions of boron in tumor.

Materials And Methods: BALB/c nude mice bearing SAS human oral carcinoma xenografts were intravenously injected with 400 mg/kg of boronophenylalanine (BPA).

A preliminary study on using the radiochromic film for 2D beam profile QC/QA at the THOR BNCT facility.

The GAFCHROMIC(®) EBT2 dosimetry film has been studied as a rapid QC/QA tool for 2D dose profile mapping in the BNCT beam at THOR. The pixel values of the EBT2 film image were converted to the 2D dose profile using a dose calibration curve obtained by 6-MV X-ray. The reproducibility of the 2D dose profile measured using the EBT2 film in the PMMA phantom was preliminarily found to be acceptable with uncertainties within about ±2 to ±3.