Publications by authors named "Hsiao-Mei Tsao"
A multi-trait GWAS identifies novel genes influencing albuminuria.
Nephrol Dial Transplant
December 2024
Article Synopsis
- - This study investigated the genetic factors associated with albuminuria, a condition linked to kidney and heart disease, by utilizing a multi-trait analysis method to examine kidney-related traits from the Taiwan Biobank data.
- - Researchers identified 15 genetic loci related to urine albumin levels, including 12 that were previously unknown, and found a strong connection between these loci and the presence of microalbuminuria.
- - The results highlight the potential role of primary cilia in kidney function and suggest the need for further research into identified genes to develop strategies for reducing albuminuria.
Background/purpose: Predictive modeling aids in identifying patients at high risk of adverse events. Using routinely collected data, we report a competing risk prediction model for kidney failure.
Methods: A total of 5138 patients with CKD stages 3b-5 were included and randomized into the development and validation cohorts at a ratio of 7:3.
The effects of lipid-lowering drugs (LLDs) on cardiovascular and renal outcomes in patients with advanced chronic kidney disease (CKD) and dyslipidemia are not completely understood. We conducted a retrospective cohort study to evaluate the effect of LLDs on end-stage kidney disease (ESKD), major adverse cardiovascular events (MACEs), and mortality in adult patients with CKD stage 3b, 4, or 5, and dyslipidemia. Participants were recruited between January 1, 2008, and December 31, 2018, and classified as LLD or non-LLD users; the final follow-up date was December 31, 2020.
View Article and Find Full Text PDFArticle Synopsis
- Frailty is an age-related condition affecting patients on peritoneal dialysis (PD), with the study assessing how frailty changes over time among new-onset and prevalent PD patients.
- The study involved 337 patients, revealing that a significant number (59.3% frail by frailty index) were frail, and predictors included older age, diabetes, and sleep disorders.
- While frailty negatively impacted patient outcomes, particularly in survival and hospitalizations, certain comorbidities like diabetes and low body mass index were identified as stronger predictors of adverse outcomes than frailty alone.
Background: The glomerular filtration rate (GFR) decline varies in patients with advanced chronic kidney disease (CKD), and the concurrent changes in CKD-related biomarkers are unclear.
Objectives: This study aimed to examine the changes in CKD-related biomarkers along with the kidney function decline in various GFR trajectory groups.
Design: This study was a longitudinal cohort study originated from the pre-end-stage renal disease (pre-ESRD) care program in a single tertiary center between 2006 and 2019.
Objective: To evaluate the association between serum urate and risk of incident chronic kidney disease (CKD) and to assess whether serum urate plays a causal role in CKD.
Patients And Methods: We conducted a prospective cohort study and Mendelian randomization analysis that analyzed longitudinal data from the Taiwan Biobank between January 1, 2012, and December 31, 2021.
Results: A total of 34,831 individuals met the inclusion criteria, of which 4697 (13.
(1) Objective: To assess the risks of gestational hypertension/preeclampsia (GH-PE) in women with prepregnancy endocrine and autoimmune disorders such as polycystic ovarian syndrome (PCOS) and systemic lupus erythematosus (SLE). (2) Methods: In a nationwide population-based longitudinal study, data were retrieved from the 1998 to 2012 Taiwan National Health Insurance Research Database. ICD9-CM codes 256.
View Article and Find Full Text PDFAccurate, complete, and timely disease surveillance data are vital for disease control. We report a national scale effort to automatically extract information from electronic medical records as well as electronic laboratory systems. The extracted information is then transferred to the centers of disease control after a proper confirmation process.
View Article and Find Full Text PDFObjective: To investigate the association between preceding endometriosis and gestational hypertension-preeclampsia (GH-PE).
Methods: In this nationwide population-based longitudinal study, data from 1998-2012 Taiwan National Health Insurance Research Database were used. We used ICD9-CM codes 617.
The cause-effect relationship between iron deficiency anemia (IDA) and osteoporosis has not been established in the general population. Thus, the current longitudinal study determined the role of IDA as a risk factor for osteoporosis by analyzing a large nationwide population-based sample. In a sample of 1,000,000 randomly sampled individuals from the 1998-2012.
View Article and Find Full Text PDFObjective: To evaluate the risk of subsequent primary ovarian insufficiency (POI) amongst patients with a history of polycystic ovarian syndrome (PCOS).
Methods: This nationwide, population-based study is an inspection and review of data from the 1998 to 2012 Taiwan National Health Insurance Research Database. In a sample of 1,000,000 randomly sampled individuals, women with PCOS (exposure group; n = 7,049) and women without PCOS (contrast group; n = 70,490) were compared.
An association may exist between obstructive sleep apnea (OSA) and depression. However, results regarding this association are inconsistent, and the direction of the association between OSA and depression remains unknown. Therefore, we used the Taiwan National Health Insurance Research Database to investigate the bidirectional association between OSA and depression.
View Article and Find Full Text PDFObjective: This nationwide population-based study aims to explore the relationship between polycystic ovarian syndrome (PCOS) and subsequent gestational diabetes mellitus (GDM).
Methods: Data from 1998-2012 Taiwan National Health Insurance Research Database were used for this study. ICD9-CM codes 256.
Background: Emerging infectious diseases continue to pose serious threats to global public health. So far, however, few published study has addressed the need for manpower reallocation needed in hospitals when such a serious contagious outbreak occurs.
Aim: To quantify the demand elasticity of the major surgery types in order to guide future manpower reallocation during contagious outbreaks.
Unlabelled: Abstract Background: The National Health Insurance program (NHI) in Taiwan has provided hospice services since 2000, and it was expanded to noncancer illnesses in September 2009. The issues of noncancer hospice care and the impact of the expanded hospice policy remain unclear.
Methods: Data were collected retrospectively from claims data of hospice admissions using the NHI Research Database of 2005-2010.