Publications by authors named "Hsiao-Chieh Wang"
J Agric Food Chem
September 2010
Article Synopsis
- Cancer metastasis is a major contributor to cancer-related deaths, and hispolon, a compound from the mushroom Phellinus linteus, shows potential as an anticancer agent.
- In studies, hispolon reduced the invasion and movement of highly metastatic SK-Hep1 cancer cells without being toxic, while decreasing key proteins like MMP-2, MMP-9, and uPA involved in metastasis.
- The mechanism involves hispolon inhibiting specific signaling pathways (ERK1/2, PI3K/Akt, and FAK), suggesting its potential as an effective treatment to prevent cancer spread.
