Publications by authors named "Hsiang-Yi Chiu"
Article Synopsis
- - Type 2 diabetes mellitus (T2DM) is linked to cancer progression due to insulin's role in promoting cell growth, while medications like metformin show potential anticancer effects.
- - The study reveals that insulin increases expression of key regulators (c-Myc, SREBP1, ACC1) which support lipogenesis and cell proliferation by affecting DNA methylation processes, specifically through the action of thymine DNA glycosylase (TDG).
- - Metformin activates AMPK, which inhibits TDG, leading to changes in DNA methylation that ultimately suppress cancer progression, highlighting TDG as a potential target for cancer treatment in T2DM patients.
The study of cnidarian-dinoflagellate endosymbiosis in octocorals is becoming increasingly important. As symbiotic gastrodermal cells (SGCs) are the key cells in a symbiotic relationship, obtaining SGCs and studying their functions represent an urgent need. The majority of the cells dissociated from octocoral tissues consist of host cells and algal cells, and very few intact SGCs can be observed.
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