Publications by authors named "Hsiang-Ping Wen"
Article Synopsis
- Fluoromethylcholine ([F]FCH) is an effective imaging agent for tumors, and a new automated synthesis method has been developed to produce it efficiently for research purposes.
- The synthesis uses a modified TRACERlab Fx module to fluorinate dibromomethane, resulting in [F]FBM, which is then combined with dimethylaminoethanol to create [F]FCH.
- The new method achieves a radiochemical yield of about 18.8%, with high purity and minimal residual impurities, making it suitable for pre-clinical and clinical applications, particularly at sites without a cyclotron.
Objective: PET imaging with (18)F-FDOPA has been successfully applied in the diagnosis and surveillance of neuroblastoma (NB) by targeting the overexpression of aromatic L-amino acid decarboxylase. This study aims to assess the impact of residual (18)F-fluoride on (18)F-FDOPA PET in NB and to implement a method to maintain low (18)F-fluoride content in future studies.
Methods: Automatic synthesis of (18)F-FDOPA was based on the electrophilic method using TRACERlab FXFE module.
Recent advances in biomarkers provide the possibility of early or preclinical diagnosis of Alzheimer's pathology. Currently, decreased levels of Aβ-42 and increased levels of tau proteins in cerebral spinal fluid are considered reliable biomarkers of Alzheimer's disease (AD); however, little evidence exists for the use of amyloid and tau protein levels in the plasma as useful biomarkers. We investigated the potential use of plasma biomarkers to diagnose AD and explored their relationships with brain Aβ deposition in amyloid imaging.
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