Oral mucosal injury caused by mammalian target of rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice.

In recent years oral mucosal injury has been increasingly recognized as an important toxicity associated with mammalian target of rapamycin (mTOR) inhibitors, including in patients with breast cancer who are receiving everolimus. This review addresses the state-of-the-science regarding mTOR inhibitor-associated stomatitis (mIAS), and delineates its clinical characteristics and management. Given the clinically impactful pain associated with mIAS, this review also specifically highlights new research focusing on the study of the molecular basis of pain.

Nursing Roles in Cardiac Safety: Romidepsin in Patients With T-Cell Lymphoma.

Purpose/objectives: To provide information to help nurses mitigate cardiac risks among patients receiving romidepsin (Istodax®), a histone deacetylase (HDAC) inhibitor approved by the U.S. Food and Drug Administration for the treatment of relapsed/refractory cutaneous and peripheral T-cell lymphoma.

Nursing Implications of Chemotherapy Agents and Their Associated Side Effects in Patients With Pancreatic Cancer.

Background: Survival for patients with advanced (locally advanced unresectable and metastatic disease) pancreatic cancer is very poor; however, several advances in treatment have been made during the past several years. Gemcitabine (Gemzar®)-based regimens, FOLFIRINOX, and nab-paclitaxel (Abraxane®)-based regimens have demonstrated efficacy in patients with advanced pancreatic cancer. Understanding the unique safety profile of each of these regimens is crucial in helping nurses identify symptoms, develop patient education strategies, and ultimately improve outcomes.

[Potentiation of the effects of anxiolytics with magnesium salts].

In a double blind trial the authors tested the assumption that magnesium potentiates by its specific action the therapeutic effect of anxiolytics. A group of 20 women treated on account of anxious depressive neurosis was divided into two sub-groups. The first was given anxiolytic and placebo, the second one anxiolytics and Mg-lactate in corresponding amounts.

[The significance of aluminum in psychiatry].

The author summarizes data from the literature on teh biological importance of aluminium, in particular its relation to the development of degenerative cerebral processes. The author discusses possibilities of the use of the protective action of zinc and magnesium in the development of dementia.

[Evoked potentials and the prediction of the efficacy of psychopharmaceutical agents].

The authors have studied early brain stem auditory evoked potentials (EPs) registered after a single intramuscular administration of 2.5 mg of haloperidol in 32 healthy volunteers and 14 schizophrenic patients. Haloperidol led to a significant decrease in the latency of wave V of brain stem auditory EPs in patients with schizophrenia and to its increase in normal subjects.