Publications by authors named "Hristo Kirov"

Background:  Rapid and accurate diagnosis of infective endocarditis (IE) allows timely management of this life-threatening disease and improves outcome. The Duke criteria have traditionally been the clinical method for diagnosing IE. These criteria were reformulated at different timepoints.

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  • CCTA is a noninvasive method for diagnosing coronary artery disease (CAD) and may guide surgical decisions, particularly before valve surgery.
  • * A meta-analysis was conducted using data from 5 studies involving 6,654 patients to compare outcomes between patients receiving ICA and CCTA.
  • * The analysis found no significant differences in perioperative mortality or secondary outcomes like AKI, MI, or stroke, suggesting that CCTA is a safe alternative to ICA.
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  • Coronary artery disease (CAD) reduces life expectancy, especially in older adults, with myocardial infarctions being a leading cause of death in people over 70.
  • A study analyzed data from 4,045 elderly patients (>70 years) who underwent coronary artery bypass grafting (CABG) to assess its impact on long-term survival compared to the general age-matched population.
  • Results showed that CABG significantly lowers the risk of death in elderly patients, suggesting that the surgery effectively prolongs life by mitigating the risks associated with CAD, particularly after the first year post-surgery.
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Background: Transcatheter Aortic Valve Implantation (TAVI) and Surgical Aortic Valve Replacement (SAVR) have different levels of invasiveness which can result in different levels of functional status after the procedure.

Methods: We performed a systematic review and meta-analysis to detect studies showing direct comparison between TAVI and SAVR regarding postoperative functional status. The primary endpoint was the incidence of postoperative delirium (POD) after TAVI or SAVR, assessed using the Confusion Assessment Method (CAM).

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  • - New-onset postoperative atrial fibrillation (POAF) is common after cardiac surgery, particularly coronary artery bypass grafting (CABG), with an estimated incidence of about 30%, but it’s often temporary and under-detected.
  • - Previous studies on POAF have used intermittent monitoring techniques that may miss many cases, leading to inaccurate assessments of how often arrhythmias occur post-surgery.
  • - The CABG-AF study aims to get a clearer picture of AF incidence and patterns after CABG by using continuous monitoring with an insertable cardiac device in 196 patients, tracking episodes over a planned follow-up of three years.
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Background: Liver dysfunction is a known risk factor in the cardiovascular field. It specifically increases perioperative risk in patients undergoing coronary bypass surgery. Since percutaneous coronary intervention (PCI) is the much less invasive procedure for the treatment of coronary artery disease, we aimed to assess the relationship of liver dysfunction with outcomes in patients undergoing PCI.

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This study aimed to conduct a systematic review and meta-analysis comparing video-assisted thoracoscopic surgery (VATS) and open thoracotomy (OT) in the context of pulmonary metastasectomy. Three databases were assessed. The primary outcome was overall survival.

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  • High-risk surgical patients often face poor outcomes due to acid-base disorders, specifically metabolic acidosis, which can be assessed using the delta anion gap to bicarbonate ratio.* -
  • This study aimed to evaluate the relationship between metabolic acidosis (MA) and complications in patients undergoing high-risk surgeries by categorizing them into three groups based on their delta AG/delta Bic values.* -
  • Results showed that out of 621 patients, a significant portion had acidosis, and those in the subgroup with no mixed disorders had a notably higher risk of 30-day mortality and cardiovascular complications.*
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Background: Aortic regurgitation (AR) is a known complication after left ventricular assist device (LVAD) implantation potentially leading to recurrent heart failure. Possible pathomechanisms include valvular pathologies and aortic root dilatation. We assessed aortic root dimensions in a group of consecutive LVAD patients who received HeartMate 3.

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The degree of both mitral (MR) and tricuspid valve regurgitation (TR) correlates with mortality. A vicious cycle has been proposed consisting of increasing regurgitation and decreasing ventricular function. Restoration of valve competence should break this vicious cycle and improve life expectancy.

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Recent randomized evidence has shown that low-dose colchicine lowers the risk of cardiovascular events in patients with chronic coronary artery disease. Colchicine has also been used in coronary artery bypass grafting (CABG), with individual studies suggesting protective effects for postoperative atrial fibrillation (POAF). We performed a meta-analysis of studies assessing the effect of colchicine on outcomes in CABG surgery.

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There is debate on the best treatment for significant stenoses of the left main (LM) coronary artery. The available evidence is based on four randomized trials, which were either performed specifically to assess patients with LM disease (EXCEL, NOBLE, PRECOMBAT) or had a significant fraction of patients with this disease pattern (SYNTAX). A meta-analysis revealed no difference in periprocedural and 5-year mortality but demonstrated a significant reduction of spontaneous myocardial infarction (MI) with CABG.

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Background: Antithrombotic therapy (ATT) in patients with infective endocarditis (IE) is challenging.

Objectives: The authors evaluated the impact of anticoagulant and antiplatelet therapy on clinical endpoints in IE patients.

Methods: We performed a systematic review and meta-analysis comparing IE patients with prior and/or ongoing use of ATT vs those without any ATT during IE course.

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Background: Complete removal of cardiac implantable electronic devices (CIEDs) is recommended in patients with CIED infections, including both systemic and localized pocket infection. The aim of the study was to provide an up-to-date and comprehensive assessment of evidence relating to the effect of complete CIED extraction in patients with a CIED infection.

Methods: We performed a systematic review and meta-analysis of studies reporting short- and mid-term outcomes in patients who had a device infection or infective endocarditis (IE) and underwent complete removal of the cardiac device (generator and leads) compared to those who received conservative therapy (no removal, partial removal, local antibiotic infiltration or isolated antibiotic therapy).

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Background:  This study aimed to assess the influence of the model of end-stage liver disease without International Normalized Ratio (INR) (MELD-XI) score on outcomes after elective coronary artery bypass surgery (CABG) without (Off-Pump) or with (On-Pump) cardiopulmonary bypass.

Methods:  We calculated MELD-XI (5.11 × ln serum bilirubin + 11.

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Objectives:  Mechanisms of coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) differ as CABG provides surgical collateralization and may prolong life by preventing future myocardial infarctions (MIs). However, evidence for CABG in patients with chronic total occlusion (CTO) has not been fully elucidated and the impact of PCI is discussed controversially.

Methods:  We performed a meta-analysis of studies comparing outcomes in patients with/without multivessel disease undergoing CABG or PCI for CTO.

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Left ventricular assist devices (LVADs) are excellent therapies for advanced heart failure patients either bridged to transplant or for lifetime use. LVADs also allow for reverse remodeling of the failing heart that is often associated with functional improvement. Indeed, growing enthusiasm exists to better understand this population of patients, whereby the LVAD is used as an adjunct to mediate myocardial recovery.

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We reviewed the cardiac surgical literature for 2023. PubMed displayed almost 34,000 hits for the search term "cardiac surgery AND 2023." We used a PRISMA approach for a results-oriented summary.

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  • The study investigated the outcomes of extracorporeal life support (ECLS) in patients who underwent surgery for acute type A aortic dissection (ATAAD), finding limited documentation on its effectiveness.
  • The systematic review included 12 observational studies with 280 patients, revealing high complication rates: in-hospital mortality was 62.8%, and many suffered from neurological issues, bleeding, and renal failure.
  • The research concluded that while ECLS is linked to significant risks, it can still provide a chance for survival in critical cases, suggesting that it should not be avoided by surgeons post-surgery for ATAAD.
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Background: Subclinical hypothyroidism (SCH) is associated with major adverse cardiovascular events. Despite the recognized negative impact of SCH on cardiovascular health, research on cardiac postoperative outcomes with SCH has yielded conflicting results, and patients are not currently treated for SCH before cardiac surgery procedures.

Methods: We performed a study-level meta-analysis on the impact of SCH on patients undergoing nonurgent cardiac surgery, including coronary artery bypass grafting and valve and aortic surgery.

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(1) : The use of extracorporeal membrane oxygenation (ECMO) in low cardiac output states after cardiac surgery may aid in patient recovery. However, in some patients, the clinical state may worsen, resulting in multiple organ failure and high mortality rates. In these circumstances, calculating a model of end-stage liver disease (MELD) score was shown to determine organ dysfunction and predicting mortality.

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Objective: Minimally invasive cardiac surgery (MICS) is increasing worldwide. In most cases, the surgical technique includes cannulation of the groin for the establishment of cardiopulmonary bypass, requiring a second surgical incision (SC) for exposure and cannulation of the femoral vessels. With the introduction of arterial closure devices, percutaneous cannulation (PC) of the groin has become a possible alternative.

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Benefits of tricuspid valve repair (TVR) in left ventricular assist device (LVAD) patients have been questioned. High TVR failure rates have been reported. Remaining or recurring TR was found to be a risk factor for right heart failure (RHF).

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Synopsis of recent research by authors named "Hristo Kirov"

  • - Hristo Kirov's recent research focuses on cardiovascular topics, specifically examining postoperative complications such as atrial fibrillation post-CABG and the impacts of liver dysfunction on outcomes after percutaneous coronary intervention (PCI).
  • - The studies conducted include systematic reviews and meta-analyses, evaluating treatment techniques like video-assisted thoracoscopic surgery versus open thoracotomy for lung metastases and antithrombotic therapy in infective endocarditis patients.
  • - Findings highlight significant associations between various clinical factors, such as regurgitation severity and mortality, underlining the importance of tailored interventions in high-risk surgical patients and the need for better understanding of postoperative arrhythmia patterns.