Publications by authors named "Hristo B Houbaviy"
Article Synopsis
- Respiration in eukaryotes relies on mitochondrial protein synthesis, which is guided by organelle-specific ribosomes that translate mitochondrial mRNAs, although many details of this process remain unclear.
- Researchers mapped the 3' ends of mitochondrial mRNAs in different yeast species and identified sequence elements called 3'-end RNA processing elements (3'-RPEs), essential for processing mitochondrial RNA.
- The study highlights the role of the Rmd9 protein in this processing, showing its interaction with 3'-RPEs across various yeast species, and uncovers a unique translation mechanism involving removed stop codons in certain mRNAs.
Article Synopsis
- The miR-290-295 cluster in mice and its human equivalent, miR-371-373, are mainly active in early embryonic development and germ cells, with some similarities in their seed sequences.
- Sequence analysis indicates that while the mouse cluster has seven pre-miRNAs, the human cluster only has three, yet most of the fundamental seed sequences are preserved between them.
- The study suggests an evolutionary model for these miRNA families based on their shared seed repertoires, which is crucial for understanding their interactions with target genes.
Mouse microRNAs (miRNAs) miR-290-miR295 are encoded by a cluster of partially homologous pre-miRNA hairpins and are likely to be functionally important in embryonic stem (ES) cells and preimplantation embryos. We present evidence that a spliced, capped, and polyadenylated primary transcript spans this entire Early Embryonic microRNA Cluster (EEmiRC). Partial Drosha processing yields additional large nuclear RNA intermediates.
View Article and Find Full Text PDFWe have identified microRNAs (miRNAs) in undifferentiated and differentiated mouse embryonic stem (ES) cells. Some of these appear to be ES cell specific, have related sequences, and are encoded by genomic loci clustered within 2.2 kb of each other.
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