Synthesis of chitin-glucan-aldehyde-quercetin conjugate and evaluation of anticancer and antioxidant activities.

In the present study, we have synthesized chitin-glucan-aldehyde-quercetin (chi-glu-ald-que) conjugate via condensation reaction. Synthesis of chitin-glucan-aldehyde (chi-glu-ald) complex was facilitated by the oxidation of chitin-glucan (chi-glu) complex. Formation of conjugate was confirmed by Proton nuclear magnetic resonance spectroscopy (H NMR) and Fourier-transform infrared spectroscopy (FT-IR).

In-vitro toxicity induced by quartz nanoparticles: Role of ER stress.

In recent years with the advancement of nanotoxicology, the scientific communities drastically increased the investigation of the potential toxicity of nanominerals which are present in all atmospheres as well as are used in a variety of applications. In this study, we reported how Quartz Nanoparticles (QNPs) depending on concentration induces different signature ER stress markers in A549 cells. QNPs induced concentration-dependent decrease in cell viability and this concentration dependent toxicity intensifies production of reactive oxygen species leading to oxidative stress and inflammation.

Evaluation of the DNA damaging potential of indigenous health hazardous quartz nanoparticles on the cultured lung cells.

Quartz nanoparticles (QNPs) cause various diseases in the biological systems and are thus considered as hazardous materials; however, their properties are important in a wide range of biological and pharmaceutical entities. The present study was initiated to enhance the understanding of the genotoxic potential and focused on the mechanism involved in the indigenous quartz nanoparticles induced toxicity in A549 cells. The results show a concentration dependent decrease in the cell viability of A549 cells.

Highly luminescent chitosan-L-cysteine functionalized CdTe quantum dots film: synthesis and characterization.

The present work describes synthesis of water soluble L-cysteine-functionalized CdTe quantum dots (QDs) with size tunable emission at different time intervals for chitosan based film. The characterization of the synthesized CdTe QDs-chitosan film was made by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermo gravimetric analysis (TGA) and scanning electron microscope (SEM). The optical property of CdTe QDs-chitosan film was determined by UV-vis and photo-luminescence (PL) spectroscopy whereas their antibacterial activity was screened for Gram positive (Staphylococcus aureus) as well as Gram negative (Pseudomonas aurigionasa and Escherichia coli) bacteria by disc diffusion method.