The effect of gender on early colonic anastomotic wound healing.

Purpose: Clinically, male patients subjected to colorectal surgery are more prone to develop anastomotic leakage than female patients by unknown mechanisms. Our aim was to investigate the impact of gender on anastomotic wound healing using an experimental model.

Methods: One-layer colonic anastomosis was constructed in 8-week-old 28 male and 32 female Sprague-Dawley rats.