Publications by authors named "Hranush H Arzumanyan"
Article Synopsis
- African swine fever virus prompts infected G0 cells to transition to the S phase of the cell cycle, only to later halt their progression in the G2 phase.
- DNA synthesis in the infected cells begins around 10-12 hours post-infection, driven by the activation of specific viral genes linked to nucleotide synthesis and cell cycle regulation.
- The virus manipulates the cell cycle to exploit the host cell’s resources for nucleotide synthesis, while later interactions with nucleotides reduce the transcriptional activity of genes involved in replication.
Article Synopsis
- The study examined how two strains of African swine fever (ASF) viruses affect the activation of porcine alveolar macrophages (AM), noting differences in immune response.
- Cells infected with the virulent ASFV-Georgia2007 showed unique M1 polarization and changes in morphology, resulting in lower synthesis of certain interferons compared to those infected with the attenuated strain ASFV-BA71V.
- The findings suggest that the more virulent ASFV-Georgia2007 reduces the antiviral response of AM, indicating that the evolutionary decrease of ASFV virulence is linked to changes in host immune system regulation.
Aim: The aim of this research was to study the effect of rabbit hemorrhagic disease virus (RHDV) on the host immune response by examining the cellular composition/pathology of lymphoid organs and serum levels of tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ).
Materials And Methods: Nine adult rabbits were inoculated with 1 ml of 10% infected liver homogenate, and three rabbits served as controls. The rabbit hemorrhagic disease (RHD)-induced animals were studied on 3 consecutive days post-infection.
The present study describes the gross, histopathologic lesions of the heart arising in pigs infected with acute African Swine Fever (ASF) and their biochemical profile. Ten pigs were infected by intramuscular injection of ASF virus (Georgia 2007). Selected heart samples were submitted for histopathological examination and Hematoxylin-Basic Fuchsin-Picric Acid (HBFP) staining.
View Article and Find Full Text PDFThe brains of 10 infected pigs were examined for histopathology and presence of African swine fever virus (ASFV) DNA ASFV infection induces inflamed meninges, cerebral edema and vascular thrombosis, as well as subdural hematomas. Slight tension in the dura mater, flattening of the gyri and narrowing of the sulci were also observed at four days post infection (dpi). Enlarged perivascular spaces were detected for most vessels of the brain after three to four dpi.
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