Fluorescence spectroscopic study on malignant and premalignant oral mucosa of patients undergoing treatment: An observational prospective study.

Background: To evaluate the changes of oral mucosa in malignancy and pre-malignant oral conditions using fluorescence spectroscopy during various phases of treatment.

Material And Methods: The study involved patients of squamous cell carcinoma of the oral cavity and the premalignant lesions coming for the follow up/post-operative radiotherapy. The autofluorescence spectra were recorded in vivo using a Nitrogen laser based fluorimeter.