The dynamics of infectious disease in a population critically involves both within-host pathogen replication and between host pathogen transmission. While modeling efforts have recently explored how within-host dynamics contribute to shaping population transmission, fewer have explored how ongoing circulation of an epidemic infectious disease can impact within-host immunological dynamics. We present a simple, influenza-inspired model that explores the potential for re-exposure during a single, ongoing outbreak to shape individual immune response and epidemiological potential in non-trivial ways.
View Article and Find Full Text PDFSavanna ecosystems are shaped by the frequency and intensity of regular fires. We model savannas via an ordinary differential equation (ODE) encoding a one-sided inhibitory Lotka-Volterra interaction between trees and grass. By applying fire as a discrete disturbance, we create an impulsive dynamical system that allows us to identify the impact of variation in fire frequency and intensity.
View Article and Find Full Text PDFThe current definition of rate-induced tipping is tied to the idea of a pullback attractor limiting in forward and backward time to a stable quasi-static equilibrium. Here, we propose a new definition that encompasses the standard definition in the literature for certain scalar systems and includes previously excluded N-dimensional systems that exhibit rate-dependent critical transitions.
View Article and Find Full Text PDFBackground: College and university students experience substantial morbidity from influenza and influenza-like illness, and they can benefit substantially from vaccination. Public health authorities encourage vaccination not only before the influenza season but also into and even throughout the influenza season. We conducted the present study to assess the impact of various vaccination strategies including delayed (i.
View Article and Find Full Text PDFAn efficient beam-combining technique based on aperture filling is introduced to direct virtually all the energy of a mutually coherent laser array to the far-field main lobe. A comparison between this method and the Dammann grating method for beam superposition reveals the connection between the two and suggests specific applications for each.
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