Publications by authors named "Howard Hua Yang"
Article Synopsis
- - VPS35, a key protein in the retromer complex that helps regulate endosomal trafficking, is genetically linked to Parkinson's disease and is associated with visual impairment in affected individuals.
- - Research findings show that mouse retinas lacking VPS35 exhibit significant synapse loss, vision deficits, and progressive degeneration tied to the formation of Lewy body-like inclusions and aggregation of a protein called phospho-α-synuclein (P-αSyn).
- - The study reveals that VPS35 interacts with another protein, HSC70, and a deficiency in VPS35 leads to the accumulation of aggregates in late endosomes, activating microglia which can be seen in live imaging as bright dots, marking the onset of pathology
Article Synopsis
- * Lipid-rich drusen are characteristic features of dry AMD, and studying AMD mouse models helps researchers understand how drusen form and contribute to the disease.
- * Research shows that mice lacking the CLIC4 protein in retinal pigment epithelium display key characteristics of dry AMD, suggesting that problems with lipid metabolism in these cells lead to drusen formation and disease progression.
Purpose: To use micro-ribonucleic acid (microRNA) profiles in the vitreous for differential diagnosis of primary vitreoretinal lymphoma and uveitis.
Design: Prospective cross-sectional study.
Methods: This prospective cross-sectional study included 17 diffuse large B-cell primary vitreoretinal lymphoma and 12 uveitis patients.