Cardiac events among patients with sarcoma treated with doxorubicin by method of infusion: A real-world database study.

Background: Administration of doxorubicin by continuous intravenous (CIV) infusion, versus bolus (BOL) administration, has been proposed to mitigate the risk of cardiac events. This study used real-world data to explore the association between mode of doxorubicin administration and duration of treatment, time-to-treatment failure (TTF), and cardiac events.

Methods: Occurrence of cardiac events after initiation of BOL versus CIV doxorubicin for sarcoma in the International Business Machines MarketScan claims database were compared.

Lower limb compartment syndrome as a complication of radical hysterectomy.

•Compartment syndrome is a rare complication of prolonged lithotomy position.•We report a case of compartment syndrome complicating radical hysterectomy.•Prompt diagnosis is crucial to reduce morbidity from compartment syndrome.

Robotic-Assisted Gynecologic Surgery and Perioperative Morbidity in Elderly Women.

Study Objective: To assess perioperative complications, conversions, and operative times in patients age ≥75 years undergoing robotic-assisted gynecologic surgery.

Design: Retrospective cohort study (Canadian Task Force classification II-2).

Setting: High-volume, 2-physician gynecologic oncology practice.

Hydrothorax after robotic-assisted surgical staging of endometrial cancer.

► Hydrothorax from a pleuroperitoneal leak is a rare complication of laparoscopy. ► First case report of hydrothorax during robot-assisted laparoscopic surgery. ► Consider hydrothorax if new onset respiratory compromise after laparoscopy.

Combined weekly topotecan and biweekly bevacizumab in women with platinum-resistant ovarian, peritoneal, or fallopian tube cancer: results of a phase 2 study.

Background: A phase 2 trial was conducted to determine the toxicity and efficacy of combined weekly topotecan and biweekly bevacizumab in patients with primary or secondary platinum-resistant ovarian, peritoneal, or fallopian tube cancer (OC).

Methods: Patients were treated with bevacizumab 10 mg/kg on days 1 and 15 and topotecan 4 mg/m(2) on days 1, 8, and 15 of a 28-day cycle until progressive disease (PD) or excessive toxicity. The primary endpoint was progression-free survival (PFS); secondary objectives included overall survival (OS), objective response, and toxicity.

Leukocytosis after robotic hysterectomy: commonly observed but clinically insignificant.

Laboratory studies are commonly performed after surgery, but with little evidence of clinical utility. We evaluated our experience with measuring a complete blood count (CBC) to determine peripheral blood leukocyte count (WBC) postoperatively following consecutive robotic hysterectomies. From January 2008 through November 2009, two surgeons (KM, HM) performed 204 robotic hysterectomies.

Robot-assisted total laparoscopic hysterectomy in obese and morbidly obese women.

Total laparoscopic hysterectomy (TLH) in obese patients is challenging. We sought to evaluate whether total laparoscopic hysterectomies using the da Vinci robotic system in obese patients, in comparison with non-obese patients, is a reasonable surgical approach. One-hundred consecutive robot-assisted TLHs were performed over a 17-month period.

Phase 2 study of intraperitoneal topotecan as consolidation chemotherapy in ovarian and primary peritoneal carcinoma.

Background: Intravenous topotecan is approved for the treatment of ovarian cancer (OC). In intraperitoneal (i.p.

Incidence and management of abdominal sacrocolpopexy mesh erosions.

Objective: This study was undertaken to evaluate the occurrence and management of mesh erosions in patients undergoing abdominal sacrocolpopexy.

Study Design: A retrospective chart review of the abdominal sacrocolpopexy procedure (n = 92) between 1997 and 2003 was performed. Patients with mesh erosion were identified.

High complication rate identified in sacrocolpopexy patients attributed to silicone mesh.

Objectives: To report on our experience using a preconfigured Y-shaped silicone-coated polyester mesh and polypropylene mesh for vaginal vault suspension. A variety of materials have been used for both open and laparoscopic sacrocolpopexy in the management of vaginal vault prolapse. Recently, a preconfigured Y-shaped silicone-coated polyester mesh was introduced to facilitate the vaginal cuff suspension to the sacrum.

Frequency of symptoms of ovarian cancer in women presenting to primary care clinics.

Context: Women with ovarian cancer frequently report symptoms prior to diagnosis, but distinguishing these symptoms from those that normally occur in women remains problematic.

Objective: To compare the frequency, severity, and duration of symptoms between women with ovarian cancer and women presenting to primary care clinics.

Design, Setting, And Patients: A prospective case-control study of women who visited 2 primary care clinics (N = 1709) and completed an anonymous survey of symptoms experienced over the past year (July 2001-January 2002).

The significance of psammoma bodies in screening cervical cytologic smears.

Objective: Although the presence of psammoma bodies in cervical cytologic smears has been associated previously with gynecologic malignancies, the clinical significance of this finding in asymptomatic women who undergo routine cervical cytologic screening has not been well defined.

Study Design: For this retrospective clinicopathologic study, a search of the Virginia Mason Medical Center computerized cytology registry from 1993 through March 2002 identified 25 evaluable cervical cytologic smears that contained psammomatous calcifications. Slides were reviewed, and clinical information was obtained from medical records.

Evaluation of p27 in preinvasive and invasive malignancies of the cervix.

Objective: p27 is a cell cycle inhibitor whose loss is commonly found in epithelial tumors. Low levels have been associated with poor prognosis. Our goal was to determine if p27 expression could be used to screen for dysplasia and if it is a prognostic factor for cervical malignancies.