Molecular Physiological Evidence for the Role of Na-Cl Co-Transporter in Branchial Na Uptake in Freshwater Teleosts.

The gills are the major organ for Na uptake in teleosts. It was proposed that freshwater (FW) teleosts adopt Na/H exchanger 3 (Nhe3) as the primary transporter for Na uptake and Na-Cl co-transporter (Ncc) as the backup transporter. However, convincing molecular physiological evidence to support the role of Ncc in branchial Na uptake is still lacking due to the limitations of functional assays in the gills.