Publications by authors named "Houze L"
Article Synopsis
- Monitoring antimalarial drug resistance in Africa is crucial due to changing responses to treatments, particularly in Eastern Africa.
- A study analyzed antimalarial susceptibility in 805 isolates from travelers returning to France, revealing significantly decreased susceptibility to lumefantrine and monodesethylamodiaquine from 2019-2023 compared to 2016-2018.
- The research indicates low levels of artemisinin resistance markers but highlights a concerning decline in effectiveness of widely used partner drugs, suggesting a need for enhanced monitoring efforts.
Given the altered responses to both artemisinins and lumefantrine in Eastern Africa, monitoring antimalarial drug resistance in all African countries is paramount. We measured the susceptibility to six antimalarials using growth inhibition assays (IC ) for a total of 805 isolates obtained from travelers returning to France (2016-2023), mainly from West and Central Africa. Isolates were sequenced using molecular inversion probes (MIPs) targeting fourteen drug resistance genes across the parasite genome.
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- GLP1R is an important target for medications used in treating type 2 diabetes and obesity, but its genetic variability affects receptor function and metabolic traits in complex ways.
- A study analyzed 60 GLP1R variants and found a range of effects, from loss of function to enhanced signaling, revealing that some variants lead to defective insulin secretion, which can be improved using specific ligands or drugs.
- Research involving 200,000 participants links poor GLP1R expression to worse glucose control and higher body weight, suggesting that impaired GLP1R function is a risk factor for type 2 diabetes and obesity, with new treatment options for affected individuals being explored.
Cerebral malaria (CM) is the severest form of Plasmodium falciparum infection. Children under 5 years old are those most vulnerable to CM, and they consequently have the highest risk of malaria-related death. Parasite-associated factors leading to CM are not yet fully elucidated.
View Article and Find Full Text PDF[Depression, anxiety and coping strategies in adult patients with cystic fibrosis].
Rev Mal Respir
February 2002
The considerable progress that has been made in the treatment of cystic fibrosis has significantly increased life expectancy. The multi-disciplinary approach is now considered to be a priority by centers providing care for adults with cystic fibrosis. The aim of this study was to investigate three psychological morbidities that are commonly present with this disease: depression, anxiety and poor coping mechanisms for stress.
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