Publications by authors named "Houyem Khiari"

Background: Cancer is a major cause of morbidity and mortality in Tunisia. The objectives of our study were to estimate the incidence level of the main cancer sites in Northern Tunisia in 2023 and to dress projections till 2040.

Methods: The population based cancer registry database of northern Tunisia was the source of cases of this study.

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Article Synopsis
  • - The study investigates the nutritional status of breast cancer patients undergoing chemotherapy and explores how nutrition affects the severity of chemotherapy-related digestive issues.
  • - Conducted on 107 women with an average age of 52, the study found that 41% were malnourished, 80% experienced constipation, and strong adherence to a Mediterranean diet was linked to less severe nausea and constipation.
  • - The results emphasize the importance of early nutritional intervention to enhance the tolerance and effectiveness of chemotherapy treatments in breast cancer patients.
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Background And Aim: As the presence of single nucleotide polymorphisms (SNPs) in the interleukin gene continues to be a major challenge in the development of effective therapies for digestive cancers, this case-control study was conducted to assess the possible influence of genotype, haplotype and diplotype for two SNPs (-1082A/G (rs1800896) and -592A/C (rs1800872)) located in the promoter region of gene on the incidence, severity and prognosis of colorectal cancer (CRC) in Tunisians.

Methods: gene SNPs were analyzed in 130 CRC cases and 165 healthy subjects (HS) using PCR-SSP.

Results: For the -1082A/G SNP, the comparison of genotype frequencies between cases and HS groups showed that the G allele significantly reduced CRC risk under the recessive model (GG vs.

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  • Despite a decline in cases due to vaccination, bacterial meningitis remains a significant health issue globally, particularly for children in Tunisia.
  • A study analyzed 388 confirmed pediatric bacterial meningitis cases from 2003 to 2019, showing that Streptococcus pneumoniae was the most common bacteria, followed by Neisseria meningitidis and Haemophilus influenzae.
  • The introduction of the Hib vaccine significantly reduced H. influenzae cases, while antibiotic resistance remained a concern, especially among Streptococcus pneumoniae and Neisseria meningitidis strains.
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Introduction: Oncologists are often confronted with patients at the end of their lives who are suffering. This can lead to anxiety and depressive disorders (ADD), affecting the quality of the doctors's quality of life.

Aim: To compare the level of ADD among doctors practicing at Salah Azaiez Institute (SAI) in Tunis with doctors who do not treat cancer patients, while identifying any factors associated with these disorders.

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Background: Insufficient physical activity is a risk factor for several types of cancer. Therefore, estimating the burden of cancer attributable to insufficient physical activity is essential to evaluate the effect of health promotion and prevention interventions.

Aims: We estimated the number of incident cancer cases, deaths and disability-adjusted life years (DALYs) attributable to insufficient physical activity in the Tunisian population aged 35 years and older in 2019.

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Rev Epidemiol Sante Publique

August 2022

Objective: We aimed to estimate the mortality attributable to current cigarette smoking among Tunisian individuals aged 30 years and over in 2016.

Methods: The number of deaths attributable to cigarette smoking was estimated using the population attributable fraction (PAF) method of calculation. Current cigarette smoking-related data and number of deaths by cause were obtained from a Tunisian national household survey conducted in 2016 (THES-2016) and the "Global Burden of Disease" study respectively.

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Background: Vaccination is the most effective way to fight the COVID-19 pandemic and to protect people who have a higher risk of developing severe illness and death from COVID-19 such as cancer patients. We aimed in this study to determine the acceptance rate of COVID-19 vaccination of the Salah Azaiez Institute (SAI) of cancer of Tunisia patients and to identify its associated factors.

Methods: It was a cross sectional study about patients admitted to the SAI for treatment during the month of February 2021.

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Introduction: non-communicable diseases (NCDs) are the leading cause of mortality and disability worldwide especially in developing countries such as Tunisia. We aimed to describe the national burden of non-communicable diseases in 2017 and to analyze disability-adjusted life year trends from 1990 to 2017 in Tunisia by cause and gender.

Methods: we used Joinpoint regression analysis to assess trends of the age standardized disability-adjusted life year rate from 1990 to 2017 and to determine average annual percentage change.

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Introduction: Schizophrenia, bipolar disorder and schizoaffective disorders are severe mental illnesses (SMI) associated with high levels of co-morbid psychopathology and premature mortality. Reducing delays in accessing services and providing early intervention are key strategies in preventing morbidity and mortality associated with these diseases. The pathways to psychiatric care have been studied in many countries worldwide.

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Objectives: The aim of this study was to describe trends of colorectal cancer incidence during the period 1994-2009 and to generate projections until 2024. Methods: The North-Tunisia Cancer Registry (NTCR) was the source of data for patients with CRC. This registry lists, since 1994, cases of malignant tumors in people living in North Tunisia, including the District of Tunis, the north east and the north west.

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Background: In 2008, non-Hodgkin lymphoma ranked tenth among other malignancies worldwide with an incidence of around 5 cases per 100,000 in both genders. The latest available rates in Tunisia are from 2006.

Materials And Methods: This study aimed to provide an update about NHL incidence for 2009 and its trend between 1998 and 2009 as well as a projection until 2024, using data from the Salah Azaiz Institute hospital registry and the Noth Tunisia cancer registry.

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