Publications by authors named "Hout H"
Background: Older adults at the emergency department (ED) with fall-related injuries are at risk of repeated falls. National guidelines state that the ED is responsible for initiating fall preventive care. A transmural fall-prevention care pathway (TFCP) at the ED can guide patients to tailored interventions.
View Article and Find Full Text PDFArticle Synopsis
- Poor oral health and function can lead to malnutrition, particularly among older adults, highlighting the interconnected nature of these issues.
- Data from three Dutch databases involving nearly 6,000 participants was analyzed, revealing significant associations between specific oral health problems (like broken teeth and swallowing issues) and malnutrition.
- The study emphasizes the importance of healthcare professionals addressing oral health when evaluating and treating nutritional status in older community-dwelling individuals.
Comparison of the oral health status of nursing home residents using the current and the newly developed interRAI oral health section (OHS-interRAI): a cross-sectional study.
BMC Geriatr
November 2024
Article Synopsis
- Regular dental check-ups and oral hygiene are often neglected in nursing homes, leading to poor oral health among residents; the OHS-interRAI was developed to improve the assessment of residents' oral health needs.
- A study compared the effectiveness of the traditional interRAI section to the OHS-interRAI in identifying oral health issues in over 12,000 nursing home residents, finding that the OHS-interRAI detected more oral health problems.
- While the OHS-interRAI showed higher detection rates for issues like chewing function and dry mouth, it also had more missing data, potentially due to regulatory constraints in its implementation.
Article Synopsis
- Older adults in nursing homes often have poor oral health, which can impact their overall well-being, but maintaining good oral hygiene and regular dental check-ups can prevent many issues.
- This study utilized the optimized Oral Health Section of the interRAI to assess the oral health of residents in Flemish and Dutch nursing homes, highlighting the need for caregivers to assist with oral hygiene.
- Results showed notable differences in oral health between Flemish and Dutch residents, with Flemish residents experiencing more issues like chewing difficulties and a greater need for dental referrals and hygiene assistance.
Article Synopsis
- - The study aimed to investigate the prevalence of potentially inappropriate medications (PIMs) in nursing home residents across eight countries, focusing on differences based on cognitive impairment and life expectancy.
- - Data from 3,832 residents showed that 87.9% were prescribed at least one PIM, with an average of 2.16 PIMs per person; cognitively impaired individuals had slightly fewer PIMs than those without cognitive issues.
- - The average number of PIMs varied by country, with Finland having the highest (3.23) and the UK the lowest (2.15); anti-platelets and aspirin were commonly prescribed.
Objectives: Nonpharmacologic interventions (NPIs) constitute an important part of treatment for older adults, cover a broad and diverse range of interventions, and have advantages over pharmacologic interventions (eg, limited adverse side effects). However, an unambiguous definition of NPIs is still lacking. Defining NPIs may facilitate research on this topic and enhance comparability of results between studies, and might help to face the challenges of recognition, acceptation, funding, and implementation.
View Article and Find Full Text PDFArticle Synopsis
- - This study addresses the need for better fall risk assessments for older adults injured from falls in emergency departments (ED) by proposing a transmural fall-prevention care pathway (TFCP) to ensure personalized interventions.
- - Researchers used a mixed-methods approach to evaluate implementation strategies for TFCP through the RE-AIM framework, focusing on the engagement of patients and healthcare professionals in two phases.
- - Results showed improved communication and acceptance of the TFCP from phase one to phase two, highlighting the importance of strategies like local champion involvement, education, and awareness in successfully implementing the pathway.
Article Synopsis
- - The increasing complexity of health issues among older adults makes it challenging for healthcare professionals to balance treatment benefits and risks, prompting a need for effective mortality prediction models.
- - This study systematically reviewed 22 studies with 38 unique mortality prediction models for community-dwelling seniors, finding that models based on frailty indices and machine learning demonstrated varying degrees of accuracy.
- - While some models performed well and showed potential for clinical use, there is a pressing need for standardized methodologies and further validation before widespread implementation.
Article Synopsis
- Progress in genetic diagnosis and orphan drug legislation has led to new therapies for rare neurogenetic diseases (RNDs), but challenges remain in academia, regulation, and finances.
- The study aims to create a practical framework for developing patient registries that address these challenges and enhance outcomes in care, research, and drug development for RNDs.
- A comprehensive approach combining literature review, interviews with existing registries, and feedback from various stakeholders was used to ensure the framework meets diverse needs and emphasizes key principles like accessible, independent, and trustworthy data governance.
Introduction: Older adults face a higher risk of vancomycin-related toxicity given their (patho)-physiological changes, making early management of supratherapeutic exposure crucial. Yet, data on vancomycin exposure in older adults is scarce. This study aims to compare vancomycin concentrations between older and younger patients, emphasizing supratherapeutic concentrations and the effect of patient characteristics.
View Article and Find Full Text PDFObjectives: Previous research in the general population shows more potentially inappropriate medications (PIMs) among persons with a migration background compared with persons without a migration background. This study investigated the association between non-Western (nw) migration background (MB) and dementia-specific PIMs in older adults with dementia in the Netherlands.
Design: Cohort study using routinely recorded electronic health records and administrative data.
Introduction: Previous research has raised concerns about high prevalence of drug-related problems, polypharmacy and inappropriate benzodiazepine prescribing in nursing homes (NHs) and confirmed lack of studies from Central and South-Eastern Europe. The aim of our study was to determine the prevalence and characteristics of polypharmacy, hyperpolypharmacy and inappropriate benzodiazepine prescribing in NH residents in Croatia.
Methods: Data from 226 older NH residents from five Croatian NHs were collected using the InterRAI Long-Term Care Facilities assessment form.
Background: Unplanned admissions to hospital represent a hazardous event for older people. Timely identification of high-risk individuals using a prediction tool may facilitate preventive interventions.
Aim: To develop and validate an easy-to-use prediction model for unplanned admissions to hospital in community-dwelling older adults using readily available data to allow rapid bedside assessment by GPs.
Objectives: To provide insight into the health and social care costs during the disease trajectory in persons with dementia and the impact of institutionalization and death on healthcare costs compared with matched persons without dementia.
Methods: Electronic health record data from family physicians were linked with national administrative databases to estimate costs of primary care, medication, secondary care, mental care, home care and institutional care for people with dementia and matched persons from the year before the recorded dementia diagnosis until death or a maximum of 4 years after the diagnosis.
Results: Total mean health and social care costs among persons with dementia increased substantially during the disease trajectory, mainly due to institutional care costs.
Introduction: This paper provides insight into the development of the Dutch Dementia Care and Support Registry and the lessons that can be learned from it. The aim of this Registry was to contribute to quality improvement in dementia care and support.
Methods: This paper describes how the Registry was set up in four stages, reflecting the four FAIR principles: the selection of data sources (Findability); obtaining access to the selected data sources (Accessibility); data linkage (Interoperability); and the reuse of data (Reusability).
Background: The management of persons with multimorbidity challenges healthcare systems tailored to individual diseases. A person-centred care approach is advocated, in particular for persons with multimorbidity. The aim of this study was to describe the co-creation and piloting of a proactive, person-centred chronic care approach for persons with multimorbidity in general practice, including facilitators and challenges for successful implementation.
View Article and Find Full Text PDFArticle Synopsis
- The study examines benzodiazepine (BZD) use among older adults (65+) in seven European countries, highlighting the prevalence and patterns of prescriptions.
- Among 2,865 study participants, 14.9% were BZD users, with Croatia, Spain, and Serbia showing the highest rates of use.
- Factors like female gender, anxiety, and depression were strongly linked to BZD use, revealing significant regional differences in prescribing practices across countries.
Background: Cognitive decline is a major reason for dependence and resource use in long-term care.
Objective: We explored whether social activities may prevent cognitive decline of older residents of long-term care facilities.
Methods: In a routine care cohort, 3,603 residents of long-term care facilities were assessed on average 4.
Background: Persons with multimorbidity may gain from person-centred care compared with the current protocolised chronic-disease management in Dutch general practice. Given time constraints and limited resources, it is essential to prioritise those most in need of an assessment of person-centred chronic-care needs.
Aim: To develop and validate a prioritisation algorithm based on routine electronic medical record (EMR) data that distinguishes between patients with multimorbidity who would, and those who would not, benefit from an extended person-centred consultation to assess person-centred chronic-care needs, as judged by GPs.
Deficiency of iduronate 2-sulfatase (IDS) causes Mucopolysaccharidosis type II (MPS II), a lysosomal storage disorder characterized by systemic accumulation of glycosaminoglycans (GAGs), leading to a devastating cognitive decline and life-threatening respiratory and cardiac complications. We previously found that hematopoietic stem and progenitor cell-mediated lentiviral gene therapy (HSPC-LVGT) employing tagged IDS with insulin-like growth factor 2 (IGF2) or ApoE2, but not receptor-associated protein minimal peptide (RAP12x2), efficiently prevented brain pathology in a murine model of MPS II. In this study, we report on the effects of HSPC-LVGT on peripheral pathology and we analyzed IDS biodistribution.
View Article and Find Full Text PDFMucopolysaccharidosis type II (OMIM 309900) is a lysosomal storage disorder caused by iduronate 2-sulfatase (IDS) deficiency and accumulation of glycosaminoglycans, leading to progressive neurodegeneration. As intravenously infused enzyme replacement therapy cannot cross the blood-brain barrier (BBB), it fails to treat brain pathology, highlighting the unmet medical need to develop alternative therapies. Here, we test modified versions of hematopoietic stem and progenitor cell (HSPC)-mediated lentiviral gene therapy (LVGT) using IDS tagging in combination with the ubiquitous MND promoter to optimize efficacy in brain and to investigate its mechanism of action.
View Article and Find Full Text PDFPurpose: Non-pharmacological interventions (NPIs) play an important role in the management of older people receiving homecare. However, little is known about how often specific NPIs are being used and to what extent usage varies between countries. The aim of the current study was to investigate the prevalence of NPIs in older homecare recipients in six European countries.
View Article and Find Full Text PDFArticle Synopsis
- * It involved 237 participants, using specific assessments to measure HRQOL and met needs, analyzing both self-reported and caregiver-reported data.
- * Results showed negative associations between met needs and HRQOL for both groups, indicating the importance of considering these perspectives in future research and care practices.
Objectives: Examine cognitive changes over time among nursing home residents and develop a risk model for identifying predictors of cognitive decline.
Design: Using secondary analysis design with Minimum Data Set data, cognitive status was based on the Cognitive Performance Scale (CPS).
Setting And Participants: Baseline and 7 quarterly follow-up analyses of US and Canadian interRAI data (N = 1,257,832) were completed.
Background: Routinely collected clinical data based on electronic medical records could be used to define frailty.
Aim: To estimate the ability of four potential frailty measures that use electronic medical record data to identify older patients who were frail according to their GP.
Design And Setting: This retrospective cohort study used data from 36 GP practices in the Dutch PHARMO Data Network.