Evaluation of a new transthoracic needle for biopsy of benign and malignant lung lesions.

The results of 88 transthoracic needle biopsies of lung lesions using the Rotex biopsy instrument are analyzed. Of 57 malignant lung lesions, 55 were diagnosed correctly. Two patients with false negative biopsies had technically inadequate examinations.

The significance of an air oesophagogram visualised on conventional chest radiographs.

Air may occasionally be seen outlining the entire oesophagus on conventional chest radiographs, this being referred to as an air oesophagogram. The reported causes of this radiological sign are reviewed. The chest radiographs of 24 cases of scleroderma with oesophageal involvement, and 29 cases of achalasia, have been studied.

The management of urinary fistulae following cadaveric renal transplantation.

Vesicoureteric, ureteric and calyceal fistulae in cadaver transplants may be successfully treated by early exploration and nephrostomy splintage with silastic tubing for a period of not less than 6 weeks.

Immunity in colonic tumor patients after operation: determination by leukocyte-migration inhibition.

Tumor immunity in 31 colonic tumor patients was studied by determining in vitro leukocyte-migration inhibition. In tissue culture 30 per cent inhibition of patient leukocyte migration by tumor antigen could be demonstrated in half of the patients, suggesting that they were immune. This immunity was not related to the clinical or pathologic stage of the disease and varied in different patients.

In vitro spleen leucocyte migration and phytohaemagglutinin-stimulated lymphocyte transformation of immunosuppressed mice cells. II. Cells from mice treated by azathioprine and/or immune stimulation or thymectomy.

An study of the spleen leucocyte migration ability and the phytohaemag-glutinin (PHA) stimulated peripheral lymphocyte response was made on cells derived from mice treated by azathioprine, immune stimulation, or thymectomy and azathioprine. These responses were compared with those shown by normal mice and found to be considerably depressed. Thymectomy combined with azathioprine produced the greatest change which persisted at 40 days.

In vitro spleen leucocyte migration and phytohaemagglutinin-stimulated lymphocyte transformation of immunosuppressed mice cells. I. Cells from mice treated by thymectomy and/or rabbit anti-mouse lymphocyte serum.

An study of spleen leucocyte migration ability and phytohaemagglutinin (PHA) stimulated peripheral lymphocyte transformation response was made on cells derived from mice treated by thymectomy, thymectomy and/or rabbit anti-mouse lymphocyte serum (RAMLS). These responses were compared with those shown by normal mice and found to be considerably depressed. Thymectomy combined with RAMLS treatment produced the greatest change.

An in vitro study of renal allograft recipients for cellular delayed type hypersensitivity to glomerular basement membrane and disrupted spleen cells.

An study of delayed hypersensitivity by leucocyte migration inhibition using disrupted spleen cells as a source of transplantation antigens, and soluble glomerular basement membrane (GBM) antigen, was made on the peripheral blood leucocytes of six normal subjects and eleven renal allograft recipients. There was no inhibition of migration in the control group. The cells of one allograft recipient were inhibited by disrupted spleen cells and the cells of four other recipients were inhibited by soluble GBM antigen.