Cross-cultural adaptation and validation of a French version of the Measure of Stroke Environment (MOSE) in stroke survivors in Sub-Saharan Africa.

Purpose: To investigate the psychometric properties of the MOSE-Benin, a French-language version of the Measure of Stroke Environment (MOSE) for Sub-Saharan Africa.

Materials And Methods: The original English version of the MOSE has been translated into French following the guidelines for cross-cultural adaptation. The resulting questionnaire (MOSE-Benin) was administered to a convenience sample of participants recruited in Benin, a French-speaking country.

Verbal communication disorders in brain damaged post-stroke patients in Benin.

Unlabelled: In Western countries, progress has lessened the severity of numerous sequels of verbal communication disorders (VCD). For Africa and more particularly Benin, few data on the subject are presently available.

Objective: To analyze the occurrence and development of post-stroke VCD in Benin.

Psychosocioprofessional and familial becoming of formers Buruli ulcer patients in Benin.

Unlabelled: Buruli ulcer (BU), an emerging disease caused by Mycobacterium ulcerans, causes severe impairments. In literature, no survey has been devoted to the cured patients returned back home.

Objective: To analyze the long-term psychosocial, professional and family repercussions of BU on former patients.

[Buruli ulcer - beyond the skin, impact on skeletal muscle].

Buruli ulcer (BU) is an emerging infectious disease caused by Mycobacterium ulcerans (M. ulcerans). Clinical observations from infected patients in the endemic zone of the West Africa reveal that severe M.

Mycobacterium ulcerans infections cause progressive muscle atrophy and dysfunction, and mycolactone impairs satellite cell proliferation.

Clinical observations from Buruli ulcer (BU) patients in West Africa suggest that severe Mycobacterium ulcerans infections can cause skeletal muscle contracture and atrophy leading to significant impairment in function. In the present study, male mice C57BL/6 were subcutaneously injected with M. ulcerans in proximity to the right biceps muscle, avoiding direct physical contact between the infectious agent and the skeletal muscle.

Limited repair and structural damages displayed by skeletal muscles loaded with mycolactone.

Mycolactone produced by Mycobacterium ulcerans is the toxin responsible for most of the pathology in Buruli ulcer, the cutaneous signature of a complex disease. Although mycolactone cytopathicity is well described in various in vitro and in vivo models, the effect of this molecule on mammalian skeletal muscles has not been addressed. This is particularly surprising since muscle damage is characteristic of severe Buruli ulcer.