Publications by authors named "Houminji Chen"
Both physiotherapy and medicine play essential roles in the treatment of epilepsy. The purpose of this research was to evaluate the efficacy of the combined therapy with focus ultrasound stimulation (FUS) and gastrodin (GTD) on seizures in a mouse model. Kainic acid-induced seizure mice were divided into five groups randomly: sham, FUS, saline + sham, GTD + sham and GTD + FUS.
View Article and Find Full Text PDFArticle Synopsis
- The brain-computer interface (BCI) is crucial for advancing neuroscience and understanding brain functions, with non-invasive neuromodulation techniques playing a key role in innovations.
- Researchers developed a new non-invasive closed-loop acoustic BCI (aBCI) that uses electroencephalography (EEG) to detect seizures and employs ultrasound to stimulate the vagus nerve, effectively stopping seizures in a rat model.
- The aBCI selectively targets mechanosensitive neurons in the vagus nerve, shows significant effectiveness over conventional methods, and offers a promising and safe option for treating seizure disorders non-invasively.
Transthoracic Ultrasound Improves Cardiac Function in Mice.
IEEE Trans Ultrason Ferroelectr Freq Control
February 2024
Cardiac dysfunction is a severe complication that is associated with an increased risk of mortality in multiple diseases. Cardioprotection solution that has been researched is the electrical stimulation of the vagus nerve to exert cardio protection. This method has been shown to reduce the systemic inflammatory response and maintain the immune homeostasis of the heart.
View Article and Find Full Text PDFIncreasing evidence indicates that inflammatory responses may influence brain neurochemical pathways, inducing depressive-like behaviors. Ultrasound stimulation (US) is a promising non-invasive treatment for neuropsychiatric diseases. We investigated whether US can suppress inflammation and improve depressive-like behaviors.
View Article and Find Full Text PDFThis study aimed to explore whether microRNA (miR) 223 affects microglial autophagy by targeting autophagy-related 16-like 1 (ATG16L1) in the kainic acid (KA) model of temporal lobe epilepsy (TLE). The miRNA and mRNA expression levels were quantified using quantitative real-time polymerase chain reaction (qRT-PCR), and the protein expression was investigated using western blotting. A dual-luciferase reporter assay was used to test the direct interaction between miR 223 and ATG16L1.
View Article and Find Full Text PDFObjectives: Glioma is the most common tumor of the central nervous system. In this review, we outline the immunobiological factors that interact with glioma cells and tumor microenvironment (TME), providing more potential targets for clinical inhibition of glioma development and more directions for glioma treatment.
Content: Recent studies have shown that glioma cells secrete a variety of immune regulatory factors and interact with immune cells such as microglial cells, peripheral macrophages, myeloid-derived suppressor cells (MDSCs), and T lymphocytes in the TME.