Segmental abnormalities of white matter microstructure in multiple sclerosis and neuromyelitis optica spectrum disorder identified by automated fiber quantification.

Background: Multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) are different in pathogenesis, but both could lead to white matter (WM) microstructural damage. The aim of this study was to explore the differences in the patterns of WM fiber tract damage in relapsing-remitting MS (RRMS) and NMOSD by automated fiber quantification (AFQ).

Materials And Methods: Forty-one RRMS patients, 30 NMOSD patients and 30 healthy controls (HC) underwent MRI examination.

A normative modeling approach to quantify white matter changes and predict functional outcomes in stroke patients.

Objectives: The diverse nature of stroke necessitates individualized assessment, presenting challenges to case-control neuroimaging studies. The normative model, measuring deviations from a normal distribution, provides a solution. We aim to evaluate stroke-induced white matter microstructural abnormalities at group and individual levels and identify potential prognostic biomarkers.

Increasing dominant follicular proportion negatively associated with good clinical outcomes in normal ovarian responders using the depot GnRH agonist protocol: a large-sample retrospective analysis.

Background: Currently, there is no universal criteria for the trigger time of controlled ovarian hyperstimulation (COH), especially with the emerging depot GnRH agonist protocol. It is challenging to explore an indicator that is representative of target follicle cohort development as an alternative to the conventional approach of determining the trigger time based on a few leading follicles.

Methods: This was a large-sample retrospective analysis.

Deep sequencing shows that accumulation of potentially pathogenic mtDNA mutations rather than mtDNA copy numbers may be associated with early embryonic loss.

Purpose: To explore the relationship between mitochondrial DNA quantity and heteroplasmy and early embryonic loss.

Methods: A total of 150 villous samples from patients with spontaneous abortion (SA, n = 75) or induced abortion (IA, n = 75) were collected. qPCR and next-generation sequencing (NGS) were used to test mitochondrial DNA quantity and heteroplasmy.