Publications by authors named "Houman Nourkeyhani"
Article Synopsis
- The use of gonadotropin-releasing hormone (GnRH) agonists in advanced prostate cancer can trigger a testosterone surge, leading to disease flare, which is concerning for patients.
- A common preventive strategy is to start antiandrogen treatment before GnRH agonist therapy, but this may be unsafe for patients at high risk of organ damage.
- Instead, using newer treatments like GnRH antagonists and CYP17 enzyme inhibitors can quickly lower testosterone levels without the side effects associated with antiandrogens, as demonstrated in three emergency cases.
We report the isolation of the human orthologue of the mouse Osterix (Osx/Sp7) gene, a C2H2 zinc finger transcription factor of the SP gene family and putative "master" regulator of bone cell differentiation. The human SP7 cDNA encodes a putative 431 amino acid protein that contains three consecutive C2H2 zinc finger repeats. The SP7 protein is highly conserved between mice and humans with an overall sequence identity of 95%.
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