Templating Iron(III) Oxides on DNA Molecules.

Fe(III) oxides were prepared as free nanoparticles and on DNA templates via the precipitation of Fe(III) salts with NaOH in the presence/absence of DNA. Through control of the pH and temperature, FeOOH and FeO were synthesised. The formation of templated materials FeOOH/DNA and FeO/DNA was confirmed using UV-Vis absorption and FTIR spectra.

Post transition metal substituted Keggin-type POMs as thin film chemiresistive sensors for HO and CO detection.

Chemiresitive sensing allows the affordable and facile detection of small molecules such as HO and CO. Herein, we report a novel class of Earth-abundant post transition metal substituted Keggin polyoxometalates (POMs) for chemiresistive sensing applications, with conductivities up to 0.01 S cm under 100% CO and 65% Relative Humidity (RH).

Vesicles, fibres, films and crystals: A low-molecular-weight-gelator [Au(6-thioguanosine)]Cl which exhibits a co-operative anion-induced transition from vesicles to a fibrous metallo-hydrogel.

We describe a simple coordination compound of Au(I) and 6-thioguanosine, [Au(6-tGH)]Cl, that has a rich self-assembly chemistry. In aqueous solution, the discrete complex assembles into a supramolecular fibre and forms a luminescent hydrogel at concentrations above about 1 mM. Below this concentration, the macromolecular structure is a vesicle.

Hierarchical self-assembly in an RNA-based coordination polymer hydrogel.

An RNA-based coordination polymer is formed by the aqueous reaction of Cu ions with the thionucleoside enantiomer (-)6-thioguanosine, (6tGH). The resulting polymer, [Cu(μ-S-thioG)]1, has a one-dimensional structure based on a [Cu-S] core and undergoes extensive hierarchical self-assembly transforming from oligomeric chains → rod → cable → bundle through which a fibrous gel forms, that undergoes syneresis to form a self-supporting mass. The assembly involves the formation of helical cables/bundles and, in combination with the intrinsic photoemission of the polymer, results in the material exhibiting circularly polarised luminescence (CPL).

Circularly polarised luminescence in an RNA-based homochiral, self-repairing, coordination polymer hydrogel.

The aqueous equimolar reaction of Ag(i) ions with the thionucleoside enantiomer (-)6-thioguanosine, ((-)6tGH), yields a one-dimensional coordination polymer {Ag(-)tG} , the self-assembly of which generates left-handed helical chains. The resulting helicity induces an enhanced chiro-optical response compared to the parent ligand. DFT calculations indicate that this enhancement is due to delocalisation of the excited state along the helical chains, with 7 units being required to converge the calculated CD spectra.

Models for sensing by nanowire networks: application to organic vapour detection by multiwall carbon nanotube-DNA films.

Electronic sensors for volatile organic compounds have been prepared by drop-casting dispersions of multi-wall carbon nanotubes (MWCNTs) in aqueous solutions of-DNA onto Pt microband electrodes. The MWCNTs themselves show a metal-like temperature dependence of the conductance, but the conductance of DNA/MWCNT composites has an activated component that corresponds to inter-tube tunneling. The resistance of the composite was modelled by a series combination of a term linear in temperature for the nanotubes and a stretched exponential form for the inter-tube junctions.

Preduodenal Portal Vein Associated With Intestinal Malrotation and Jejunal Atresia.

Preduodenal portal vein (PDPV) is a rare congenital anomaly commonly associated with other gastrointestinal abnormalities. We report the case of a female neonate with a PDPV, intestinal malrotation and jejunal atresia. This is the second account of this association reported in the literature.

Survival outcomes for breast cancer patients who decline recommended treatment: a propensity score-matched analysis.

Background: For patients with breast cancer who decline recommended treatments, available data examining survival outcomes are sparse. We compared overall survival and relapse-free survival outcomes between patients with breast cancer who declined recommended primary treatments and those who received recommended primary treatments.

Methods: Using data from the BreastSurgANZ Quality Audit database, a retrospective cohort study was performed for patients diagnosed with breast carcinoma (stage 0-IV) between 2001 and 2014 who were treated in our integrated cancer centre.

Observational study of falls in children from windows and balconies: What has changed?

Aim: To describe patterns of injury from window and balcony falls in children presenting to a tertiary paediatric trauma centre in New South Wales.

Methods: A retrospective review of cases of children <15 years who had sustained injuries in a fall from a building, identified from the trauma database between 1998 and 2019.

Results: A total of 381 falls from windows and balconies were recorded over the 22-year study period.

Bottom-up device fabrication the seeded growth of polymer-based nanowires.

The bottom-up assembly of nanoelectronic devices from molecular building blocks is a target of widespread interest. Herein we demonstrate an seeded growth approach to produce a nanowire-based electrical device. This exploits the chemisorption of block terpolymer-based seed fibres with a thiophene-functionalised corona onto metal electrodes as the initial step.

and Conformations in Silver-Mediated Cytosine Base Pairs: Hydrogen Bonding Dictates Argentophilic Interactions in the Solid State.

We have synthesized and structurally characterized examples of the well-known silver-mediated DNA base pair in its simplest possible form, as [Ag-bis-(N3-cytosine)]. The compounds show differences such as variable coordination geometry, conformation with and arrangements, and, in one case, intramolecular base pairing. Collectively, these compounds represent three of five permutations of linear/bent coordination geometry and / arrangement of the cytosine ligands and contain the global minimum conformation as determined by DFT calculations: bent-.

A phase II study to assess the safety and efficacy of the dual mTORC1/2 inhibitor vistusertib in relapsed, refractory DLBCL.

Patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) who are unfit for or relapsed postautologous stem-cell transplantation have poor outcomes. Historically, mTORC1 inhibitors have produced responses in approximately 30% of patients in this setting. mTORC1 inhibitor efficacy may be limited by resistance mechanisms including AKT activation by mTORC2.

Addressing the properties of "Metallo-DNA" with a Ag(i)-mediated supramolecular duplex.

The silver-nucleoside complex [Ag(i)-(3-cytidine)], , self-assembles to form a supramolecular metal-mediated base-pair array highly analogous to those seen in metallo-DNA. A combination of complementary hydrogen-bonding, hydrophobic and argentophilic interactions drive the formation of a double-helix with a continuous silver core. Electrical measurements on show that despite having Ag···Ag distances within <5% of the metallic radii, the material is electrically insulating.

PEPtalk2: results of a pilot randomised controlled trial to compare VZIG and aciclovir as postexposure prophylaxis (PEP) against chickenpox in children with cancer.

Objective: To determine the likely rate of patient randomisation and to facilitate sample size calculation for a full-scale phase III trial of varicella zoster immunoglobulin (VZIG) and aciclovir as postexposure prophylaxis against chickenpox in children with cancer.

Design: Multicentre pilot randomised controlled trial of VZIG and oral aciclovir.

Setting: England, UK.

Duplex Healing of Selectively Thiolated Guanosine Mismatches through a Cd Chemical Stimulus.

The on-column selective conversion of guanosine to thioguanosine (tG) yields modified oligomers that exhibit destabilisation over the fully complementary duplex. Restoration to a stabilised duplex is induced through thio-directed Cd coordination; a route for healing DNA damage. Short oligomers are G-specifically thiolated through a modified on-column protocol without the need for costly thioguanosine phosphoramidites.

Inkjet printing and electrical characterisation of DNA-templated cadmium sulphide nanowires.

Cadmium sulphide can be templated on λ-DNA molecules to form an aqueous dispersion of CdS/λ-DNA nanowires. Subsequent addition of ethylene glycol to 50% v/v is sufficient to formulate an ink suitable for printing using piezoelectric drop-on-demand technology. Printed droplet arrays show a coffee-ring morphology of individual deposits by fluorescence and Raman microscopy, but upon increasing the number of layers of printed material by repeated printing over each droplet, the dry deposit approaches closer to a disc shape.

Marine antifouling performance of polymer coatings incorporating zwitterions.

Zwitterionic materials display antifouling promise, but their potential in marine anti-biofouling is still largely unexplored. This study evaluates the effectiveness of incorporating small quantities (0-20% on a molar basis) of zwitterions as sulfobetaine methacrylate (SBMA) or carboxybetaine methacrylate (CBMA) into lauryl methacrylate-based coatings whose relatively hydrophobic nature encourages adhesion of the diatom Navicula incerta, a common microfouling organism responsible for the formation of 'slime'. This approach allows potential enhancements in antifouling afforded by zwitterion incorporation to be easily quantified.

Ruxolitinib vs best available therapy for ET intolerant or resistant to hydroxycarbamide.

Treatments for high-risk essential thrombocythemia (ET) address thrombocytosis, disease-related symptoms, as well as risks of thrombosis, hemorrhage, transformation to myelofibrosis, and leukemia. Patients resistant/intolerant to hydroxycarbamide (HC) have a poor outlook. MAJIC (ISRCTN61925716) is a randomized phase 2 trial of ruxolitinib (JAK1/2 inhibitor) vs best available therapy (BAT) in ET and polycythemia vera patients resistant or intolerant to HC.

A coordination polymer for the site-specific integration of semiconducting sequences into DNA-based materials.

Advances in bottom-up material design have been significantly progressed through DNA-based approaches. However, the routine integration of semiconducting properties, particularly long-range electrical conduction, into the basic topological motif of DNA remains challenging. Here, we demonstrate this with a coordination polymer derived from 6-thioguanosine (6-TG-H), a sulfur-containing analog of a natural nucleoside.

Outcome of Azacitidine Therapy in Acute Myeloid Leukemia Is not Improved by Concurrent Vorinostat Therapy but Is Predicted by a Diagnostic Molecular Signature.

Azacitidine (AZA) is a novel therapeutic option in older patients with acute myeloid leukemia (AML), but its rational utilization is compromised by the fact that neither the determinants of clinical response nor its mechanism of action are defined. Co-administration of histone deacetylase inhibitors, such as vorinostat (VOR), is reported to improve the clinical activity of AZA, but this has not been prospectively studied in patients with AML. We compared outcomes in 259 adults with AML ( = 217) and MDS ( = 42) randomized to receive either AZA monotherapy (75 mg/m × 7 days every 28 days) or AZA combined with VOR 300 mg twice a day on days 3 to 9 orally.

Nanoscale silicon substrate patterns from self-assembly of cylinder forming poly(styrene)-block-poly(dimethylsiloxane) block copolymer on silane functionalized surfaces.

Poly(styrene)-block-poly(dimethylsiloxane) (PS-b-PDMS) is an excellent block copolymer (BCP) system for self-assembly and inorganic template fabrication because of its high Flory-Huggins parameter (χ ∼ 0.26) at room temperature in comparison to other BCPs, and high selective etch contrast between PS and PDMS block for nanopatterning. In this work, self-assembly in PS-b-PDMS BCP is achieved by combining hydroxyl-terminated poly(dimethylsiloxane) (PDMS-OH) brush surfaces with solvent vapor annealing.

Two-Dimensional Frameworks Based on Ag(I)-N Bond Formation: Single Crystal to Single Molecular Sheet Transformation.

A series of new two-dimensional coordination framework materials, based on Ag(I)-N bond formation, has been synthesized and structurally characterized by single crystal methods. Reactions between the poly-monodentate bridging ligand N,N'-((1r,4r)-cyclohexane-1,4-diyl)bis(1-(pyridin-3-yl)methanimine), L1, and silver salts yield compounds {[Ag(L1)(MeCN)](CFSO)}, 1, {[Ag(L1)(PFO)]·HO}, 2, and {Ag(L1)(tosylate)}, 3. The frameworks of these materials exhibit two distinct net topologies: 3.

Metal-conductive polymer hybrid nanostructures: preparation and electrical properties of palladium-polyimidazole nanowires.

A simple, convenient method for the formation of hybrid metal/conductive polymer nanostructures is described. Polyimidazole (PIm) has been templated on λ-DNA via oxidative polymerisation of imidazole using FeCl3 to produce conductive PIm/DNA nanowires. The PIm/DNA nanowires were decorated with Pd (Pd/PIm/DNA) by electroless reduction of PdCl4(-2) with NaBH4 in the presence of PIm/DNA; the choice of imidazole was motivated by the potential Pd(II) binding site at the pyridinic N atom.