Publications by authors named "Houko Ohki"
One hallmark of some autoimmune diseases is the variability of symptoms among individuals. Organs affected by the disease differ between patients, posing a challenge in diagnosing the affected organs. Although numerous studies have investigated the correlation between T cell antigen receptor (TCR) repertoires and the development of infectious and immune diseases, the correlation between TCR repertoires and variations in disease symptoms among individuals remains unclear.
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- Medullary thymic epithelial cells (mTECs) play a vital role in teaching T cells about the body's own tissues to prevent autoimmune responses, a process regulated by the transcription factor AIRE.
- Research using advanced techniques like scATAC-seq and scRNA-seq has identified a specific type of proliferating mTECs (AireCD80) that show distinct chromatin patterns and high levels of the AIRE protein and co-stimulatory molecules like CD80.
- These proliferating mTECs initially express fewer tissue-specific antigens (TSAs) but can transition to a quiescent state where they express higher levels of TSAs, indicating a key step in their development in the postnatal thym