Publications by authors named "Houkang Lei"
Article Synopsis
- Preeclampsia (PE) is a significant topic in obstetrics research, yet its mechanisms are not fully understood, prompting the analysis of several gene expression datasets to identify differences between PE and control groups.
- Researchers established a competitive endogenous RNA (ceRNA) network, identifying five hub genes (DAXX, EFNB1, NCOR2, RBBP4, and SOCS1) linked to PE and predicted potential drugs that could interact with these genes.
- The study's findings highlight AGAP2-AS1's role in a regulatory network involving 41 mRNAs and two miRNAs, aiming to deepen the understanding of the molecular connections in PE and create a basis for future scientific exploration.
Endothelial cell dysfunction is an essential pathophysiological feature of preeclampsia (PE). It has been reported that cathepsin C is upregulated in the maternal vascular endothelium of PE patients. The excessive activation of p38 MAPK leads to various diseases, including PE.
View Article and Find Full Text PDFPregnancies complicated by pre-gestational diabetes (PGD) are associated with a higher rate of adverse outcomes, including an increased rage of preterm delivery, pregnancy-induced hypertension, pre-eclampsia, caesarean section, perinatal mortality, stillbirth, shoulder dystocia, macrosomia, small for gestational age, large for gestational age, low birth weight, neonatal hypoglycemia, neonatal death, low Apgar score, NICU admission, jaundice and respiratory distress. In the past two decades, numerous reports have been published regarding associations between PGD and risk of adverse outcomes. However, study results are inconsistent.
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