Fractions of Shen-Sui-Tong-Zhi Formula Enhance Osteogenesis Activation of β-Catenin Signaling in Growth Plate Chondrocytes.

Shen-sui-tong-zhi formula (SSTZF) has been used to treat osteoporosis for decades and shows excellent clinical efficacy. This article aims to explore the optimal anti-osteoporotic ingredient and its precise mechanisms in mice models. In this study, we first screened the optimal anti-osteoporosis fraction of SSTZF extract , and then further explored the mechanism of its effects both and .

Bushenhuoxue formula promotes osteogenic differentiation of growth plate chondrocytes through β-catenin-dependent manner during osteoporosis.

Background: Bushenhuoxue formula (BSHXF) has shown excellent clinical effects on the treatment of osteoporosis in China. The aim of this study is to determine the anti-osteoporosis effects and precise molecular mechanisms of BSHXF on mouse models.

Methods: Ten-week-old female C57BL/6 J mice were subjected to ovariectomy and provided a daily treatment of BSHXF.