Lymphoid tyrosine phosphatase R620W variant and inflammatory bowel disease in Tunisia.

Aim: To assess the possible association between PTPN22 (R620W) gene polymorphism and inflammatory bowel disease (IBD).

Methods: One hundred and sixty-four patients with IBD [105 Crohn's disease (CD) and 59 ulcerative colitis (UC)] and 100 healthy controls were recruited. Genotyping of the PTPN22 gene 1858C-->T polymorphism was performed by restriction fragment length polymorphism-polymerase chain reaction with RsaI digestion.