Publications by authors named "Hou-Yun Gu"
Spinal cord injury (SCI) is a serious and disabling central nervous system injury that can trigger various neuropathological conditions, resulting in neuronal damage and release of various pro-inflammatory mediators, leading to neurological dysfunction. Currently, surgical decompression, drugs and rehabilitation are primarily used to relieve symptoms and improve endogenous repair mechanisms; however, they cannot directly promote nerve regeneration and functional recovery. SCI can be divided into primary and secondary injuries.
View Article and Find Full Text PDFSpinal cord injury (SCI) is a severe disabling injury of the central nervous system that can lead to motor, sensory, and autonomic dysfunction below the level of the injury. According to its pathophysiological process, SCI can be divided into primary injury and secondary injury. Currently, multiple therapeutic strategies have been proposed to alleviate secondary injury and overcome the occurrence of neurodegenerative events.
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- - The study explored how connexin 43 (Cx43) influences the bone-forming ability of rat bone marrow-derived mesenchymal stem cells (BMSCs) when exposed to low-frequency-pulsed electromagnetic fields (LPEMF).
- - BMSCs were treated with LPEMF at 80 Hz for 1 hour, which led to increased cell proliferation and enhanced osteogenic markers, indicating improved bone formation capabilities.
- - Inhibiting Cx43 expression reduced the benefits seen from LPEMF, suggesting that Cx43 plays a crucial role in promoting osteogenic differentiation in BMSCs.
Spinal cord injury (SCI) is a serious disabling central nervous system injury that can lead to motor, sensory, and autonomic dysfunction below the injury level. SCI can be divided into primary injury and secondary injury according to pathological process. Primary injury is mostly irreversible, while secondary injury is a dynamic regulatory process.
View Article and Find Full Text PDFSpinal cord injury (SCI) is a severe and disabling injury of the central nervous system, with complex pathological mechanisms leading to sensory and motor dysfunction. Pathological processes, such as oxidative stress, inflammatory response, apoptosis, and glial scarring are important factors that aggravate SCI. Therefore, the inhibition of these pathological processes may contribute to the treatment of SCI.
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