Publications by authors named "Hou-Hsuan Cheng"
Purpose: We aimed to evaluate the efficacy of moderate doses of bevacizumab in combination with TAS-102 for the treatment of refractory metastatic colorectal cancer.
Methods: A total of 261 patients with refractory mCRC were enrolled and categorized into two groups: TAS-102 combined with bevacizumab and TAS-102 alone. Patients in the bevacizumab combination group were divided into two subgroups based on a median dose of 3.
Background: Locally advanced rectal tumors are typically treated with neoadjuvant chemoradiotherapy. Short-course chemoradiotherapy (SCRT, 2500 cGy in five fractions) is a convenient alternative to concurrent chemoradiotherapy with long-course radiotherapy (CCRT, 4500 cGy in 25 fractions) without sacrificing efficacy. We aimed to compare the short-term outcomes of SCRT and CCRT in patients with mid- and low- rectal tumors who underwent total mesorectal excision using real-world data.
View Article and Find Full Text PDFSalvage treatment for refractory metastatic colorectal cancer (mCRC) has yet to be identified. We aimed to evaluate the efficacy of a salvage lenvatinib-based regimen for refractory mCRC. In total, 371 patients were categorized into lenvatinib-based and non-lenvatinib-based groups.
View Article and Find Full Text PDFBackground: The clinical outcomes between left-sided colon cancer and middle/low rectal cancer seem to be different. This study aimed to examine the effect of primary tumor location regarding the left-sided colon and middle/low rectum on the overall survival (OS) of patients who underwent colorectal hepatic metastasectomy.
Methods: Patients who underwent colorectal hepatic metastasectomy were retrospectively enrolled.
Background: The role of hepatectomy in a specific group of patients with synchronous colorectal cancer with liver metastases (SCRLM) and synchronous extrahepatic disease (SEHD) is still unclear. The aim of this study was to evaluate the efficacy of liver surgery and define the selection criteria for surgical candidates in patients with SCRLM + SEHD.
Methods: Between July 2007 and October 2018, 475 patients with colorectal cancer with liver metastases (CRLM) who underwent liver resection were retrospectively reviewed.
Article Synopsis
- * Researchers collected data from 1729 colonoscopy images between May 2014 and December 2017 to test FEViT's effectiveness in predicting patient survival.
- * FEViT demonstrated a 94% accuracy rate in predicting survival, outperforming the traditional TNM staging classification (90% accuracy), making it a promising tool for better CRC prognosis.
Background: Colorectal brain metastases (CBMs) are rare with poor prognosis. There is still no standard systemic treatment for multiple or unresectable CBM. our study aimed to explore the impact of anti-VEGF therapy on overall survival, brain-specific disease control, and neurologic symptom burden in patients with CBM.
View Article and Find Full Text PDFPurpose: Protective ileostomy and colostomy are performed in patients undergoing low anterior resection with a high leakage risk. We aimed to compare surgical, medical, and daily care complications between these 2 ostomies in order to make individual choice.
Methods: Patients who underwent low anterior resection for rectal tumors with protective stomas between January 2011 and September 2018 were enrolled.
Backgrounds: Accumulating evidence has reported a high correlation between inflammatory markers and oncological outcomes in colorectal cancer. In the present study, we aimed to assess the prognostic values of five inflammatory markers in stage II colon cancer patients with different tumour locations.
Methods: The consecutive stage II colon adenocarcinoma patients undergoing curative resection were analysed retrospectively.
Background: Rectal cancer is mainly cured by radical resection with neoadjuvant chemoradiation or adjuvant chemotherapy. Pathological T1 lesions can be managed by local treatment and radiotherapy thereafter. Lower morbidity is the key benefit of these local treatments.
View Article and Find Full Text PDFBackground: Whether the timing of stoma reversal after emergency diversion for obstructive left-sided colon cancer affects patient outcomes is unknown. Our study compared the short- and long-term outcomes of two- and three-stage operations for obstructive left-sided colon cancer.
Methods: Patients with obstructive left-sided colon cancer who underwent staged resection at a referral hospital between January 2002 and December 2015 were retrospectively identified.
Article Synopsis
- The study investigates the link between colorectal cancer (CRC) and type 2 diabetes mellitus (DM), focusing on the role of collpasin response mediator protein-2 (CRMP2) in CRC progression related to metabolic imbalance.
- Researchers found that CRMP2 levels were significantly lower in tumor tissues of CRC-DM patients and that high glucose conditions reduced CRMP2 expression, which exacerbated CRC characteristics like cell proliferation and metastasis.
- The findings suggest that targeting the metabolic changes associated with CRMP2 may provide new strategies for treating both diabetes and cancer concurrently.
Tattooing or Metallic Clip Placement? A Review of the Outcome Surrounding Preoperative Localization Methods in Minimally Invasive Anterior Resection Performed at a Single Center.
Surg Laparosc Endosc Percutan Tech
October 2021
Article Synopsis
- - The study compares two preoperative localization methods for minimally invasive colorectal surgery, focusing on their impact on short-term outcomes, including operative results and complications, using real-world data.
- - It found that the group using endoscopic tattooing had better resection margins and a higher lymph node harvest compared to those using metallic clips, although both methods showed similar rates of postoperative complications and hospital stays.
- - Overall, the study concludes that preoperative localization enhances surgical planning and outcomes, with endoscopic tattooing being particularly effective in improving lymph node retrieval and reducing the need for intraoperative colonoscopy.
Given the unclear preference criteria for regorafenib in treating refractory metastatic colorectal cancer (mCRC), this study aimed to construct an algorithm in selecting right patients for regorafenib. This was a multicenter retrospective cohort study. Patients with pathology confirmed mCRC and administered with regorafenib for > 3 weeks were enrolled.
View Article and Find Full Text PDFBackground: Clinically, metastatic rectal cancer has been considered a subset of left-sided colon cancer. However, heterogeneity has been proposed to exist between high and middle/low rectal cancers. We aimed to examine the efficacy of anti-epidermal growth factor receptor (EGFR) treatment for middle/low rectal and left-sided colon cancers.
View Article and Find Full Text PDFBackground: The effects of primary tumor location on colorectal liver metastasis (CRLM) and post-hepatic-metastasectomy overall survival (OS) are controversial. This study evaluated the difference in post-hepatic-metastasectomy OS among right-sided colon, left-sided colon, and rectal cancer groups.
Methods: In total, 381 patients who underwent curative-intent CRLM resection were enrolled.
Background: Both regorafenib and reduced-intensity FOLFOXIRI (riFOLFOXIRI) prolong survival in patients with metastatic colorectal cancer (mCRC). However, the sequence in which they should be administrated first in late-line treatment for refractory mCRC remains unclear.
Patients And Methods: This study was a single-center retrospective cohort study that reviewed data from patients at Taipei Veterans General Hospital, Taiwan, with mCRC refractory to fluorouracil, irinotecan, oxaliplatin, cetuximab (wild-type RAS), and bevacizumab.
Clinical significance of the BRAFV600E mutation in Asian patients with colorectal cancer.
Int J Colorectal Dis
September 2018
Background: To investigate the clinicopathological features and prognostic significance of the BRAFV600E mutation in Asian patients with colorectal cancer.
Methods: We retrospectively reviewed the medical records of 1969 patients with colorectal cancer admitted to Taipei Veterans General Hospital for surgical treatment between 2000 and 2013. The measured endpoint was overall survival after surgery.