The neutrophil-to-lymphocyte ratio is associated with in-hospital heart failure in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention.

Objective: To explore the association between the neutrophil-to-lymphocyte ratio (NLR) and in-hospital heart failure (HF) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI).

Methods: Our present study included 413 patients diagnosed with STEMI and treated with primary PCI. We performed logistic regression models to evaluate the relationship between the NLR and in-hospital HF risk in subjects diagnosed with STEMI.

Iridium-Catalyzed Asymmetric Hydrogenation of γ- and δ-Ketoacids for Enantioselective Synthesis of γ- and δ-Lactones.

A highly efficient asymmetric hydrogenation of γ- and δ-ketoacids was developed by using a chiral spiro iridium catalyst ()-, affording the optically active γ- and δ-hydroxy acids/lactones in high yields with excellent enantioselectivities (up to >99% ee) and turnover numbers (TON up to 100000). This protocol provides an efficient and practical method for enantioselective synthesis of Ezetimibe.

Liver Enzymes and the Risk of Atrial Fibrillation: A Meta-Analysis of Prospective Cohort Studies.

The association between liver enzymes and the future development of atrial fibrillation (AF) from observational studies is unclear. We, therefore, performed a meta-analysis to systematically evaluate the relationship between liver enzymes and AF risk. We searched the PubMed and Embase databases for observational cohort studies assessing the association between liver enzymes and AF risk.