Publications by authors named "Hou Yanhong"
Purpose: To compare safety and efficacy of isolated and combined UV-light corneal crosslinking (CXL) and fine-needle diathermy (FND) to regress pathological corneal vessels in vivo.
Methods: Mice with inflamed and pathologically vascularized corneas received CXL or FND as monotherapy or a combination of both treatments. Corneal pathological blood and lymphatic vessels, immune cells and the morphology of anterior segment structures were evaluated.
Article Synopsis
- * It focuses on the Sirtuins family, which may play a beneficial role in reducing the harmful effects of DOX through mechanisms like reducing inflammation, oxidative stress, and apoptosis.
- * The study also identifies small-molecule compounds and natural substances that could regulate Sirtuins, offering promising avenues for preventing and treating DOX-induced cardiac injury.
Background: We successfully screened the important interacting protein peroxiredoxin 4 (PRDX4) of thioredoxin domain-containing protein 5 (TXNDC5) in gastric cancer. However, its specific molecular mechanism in gastric cancer remains unclear. This study aimed to verify the interaction between PRDX4 and TXNDC5 protein molecules in gastric cancer and analyze the expression and functional significance of PRDX4 in gastric cancer using bioinformatics methods.
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- - The Sirtuins family, specifically SIRT6, plays a crucial role in protecting myocardial cells from damage and aging caused by the chemotherapy drug doxorubicin (DOX), as evidenced by its ability to inhibit oxidative stress and apoptosis in these cells.
- - In laboratory tests, SIRT6 overexpression was shown to reduce aging markers and inflammatory factors linked to DOX exposure, while silencing SIRT6 worsened cardiomyocyte injury, indicating its protective effects against DOX-induced damage.
- - Furthermore, SIRT6 enhances fatty acid oxidation-related gene expression through interaction with PPARα, and in animal models, its overexpression restored normal heart function, highlighting its potential as a therapeutic target for preventing DOX
Article Synopsis
- * PARP-1 is a well-known protein that might help treat cardiovascular diseases linked to DOX, but PARP-2, another member of the PARP family, has not been well studied in this context.
- * This study reveals that reducing PARP-2 may protect heart cells from aging caused by DOX, while increasing PARP-2 worsens cell damage, indicating that targeting PARP-2 could be a promising approach for preventing DOX-related heart problems.
Article Synopsis
- The limbus, the area connecting the cornea and conjunctiva, may protect against abnormal blood vessel growth in the cornea, but how it does this isn't fully understood.
- Researchers studied ABCB5, a marker for limbal epithelial stem cells (LESCs), to explore its role in corneal blood vessel development and found it has different effects in young and adult mice.
- The study revealed that ABCB5+ cells can inhibit blood vessel growth during development but promote it during inflammation in adults, suggesting a complex role that could be important for therapies aimed at preventing blindness.
Article Synopsis
- * Researchers used event-related potentials (ERPs) to analyze brain activity related to working memory in two groups: one with normal sleep and one with sleep deprivation.
- * Results showed that while RS improved some aspects of working memory and brain function, its effects were limited after a long period of sleep deprivation.
Article Synopsis
- Functional gastroduodenal disease is a major type of gastrointestinal disorder, characterized by symptoms like epigastric pain, dyspepsia, and chronic nausea, making it common among gastroenterology outpatients.
- A study used near-infrared brain imaging to analyze brain function, alongside mental health assessments and heart rate variability, comparing patients with the condition to normal controls.
- Results indicated decreased activity in specific areas of the prefrontal lobe for patients, significant differences in mental health issues like anxiety and depression, but no notable changes in autonomic nervous system function.
Article Synopsis
- Recent research shows that lymphatic vessels, once thought absent in the eye, play a significant role in various eye diseases.
- The review explores how these vessels contribute to conditions like dry eye, corneal graft rejection, and tumors, as well as the underlying molecular mechanisms involved.
- It also highlights new therapeutic approaches based on targeting lymphangiogenesis, with promising initial results from clinical trials aimed at improving transplant survival and managing glaucoma.
Article Synopsis
- - This study aimed to compare the effectiveness of two targeted monoclonal antibodies, anti-MUC1 and anti-CA199, combined with drug-loaded nanoparticles in treating human pancreatic cancer in cell lines and animal models.
- - Researchers developed gemcitabine-loaded nanoparticles and tested their cell-killing rates and effects on cancer cell cycles and apoptosis using laboratory techniques.
- - Results showed that the MUC1-GEM-PBCA-NP treatment group had a significantly higher cell-killing rate and tumor inhibition rate (72.69%) compared to the CA199-GEM-PBCA-NP group and control groups, indicating better potential for targeting pancreatic cancer.
Article Synopsis
- - Previous research identified that Mucin 1 (MUC1) is highly expressed in pancreatic cancer and its abnormal glycosylation reveals new protein targets for treatment.
- - This study aimed to assess the effectiveness of drug-loaded gemcitabine nanoparticles combined with anti-MUC1 monoclonal antibodies in fighting pancreatic cancer in both lab cultures and live mice models.
- - Results showed that the MUC1-GEM-PBCA-NP treatment had significantly higher cell-killing and apoptosis rates in vitro, and an impressive 68.14% tumor inhibition in vivo, outperforming other treatment groups.
Article Synopsis
- Lymphatic vessel formation (lymphangiogenesis) in the cornea is a major factor influencing the rejection of corneal transplants, as these vessels play a crucial role in immune responses by sensitizing the immune system to foreign tissue.
- Various experimental methods, including UVA-based corneal collagen crosslinking and fine needle diathermy, have shown potential in reversing lymphangiogenesis and improving the success rate of corneal grafts.
- The article explores innovative strategies to temporarily reduce lymphatic vessels before transplantation, termed "lymphangioregressive preconditioning," which could enhance graft survival and may be applicable to other types of transplants in the future.
Article Synopsis
- * A study involving 26 healthy volunteers used fMRI to examine how functional connectivity changes after 36 hours of total sleep deprivation.
- * Results showed decreased connectivity between key brain areas (nucleus accumbens, anterior cingulate cortex, and inferior frontal gyrus) and a negative correlation with the participants' emotional experiences post-deprivation.
A teaching tool about the fickle p value and other statistical principles based on real-life data.
Naunyn Schmiedebergs Arch Pharmacol
June 2021
Article Synopsis
- * Researchers developed a tool using real data to help biomedical scientists grasp the variability of p values, focusing on direct experience rather than complex simulations.
- * This tool has been successfully tested across several groups, emphasizing the importance of live exercises in training scientists on statistical concepts, including the effects of randomness and sample size.
Article Synopsis
- Corneal neovascularization is a major factor leading to graft rejection in high-risk penetrating keratoplasty (PK), and corneal crosslinking (CXL) has shown promise in animal studies for reducing this issue.* -
- A study conducted on 5 patients demonstrated that CXL either alone or together with PK effectively reduced corneal neovascularization by an average of 70.5%, with no significant complications or graft rejection recorded during the follow-up period.* -
- The findings suggest that CXL could be a new therapeutic approach for enhancing graft survival rates post high-risk PK by targeting and regressing harmful corneal blood and lymphatic vessels.*
Article Synopsis
- The study explores how semifluorinated alkanes (SFAs), specifically perfluorohexyloctane (F6H8), can be used to deliver vascular endothelial growth factor (VEGF) Trap to inhibit corneal neovascularization in mice.
- Treatment with Trap/F6H8 showed comparable effectiveness to the standard aqueous VEGF Trap in reducing blood and lymph vessel formation in the cornea after two weeks.
- Results suggest that F6H8 might be a promising carrier for anti-angiogenic therapies in the eye, potentially leading to new treatments for ocular conditions involving abnormal blood vessel growth.
Coordination of a Dual-Channel Pharmaceutical Supply Chain Based on the Susceptible-Infected-Susceptible Epidemic Model.
Int J Environ Res Public Health
May 2020
Article Synopsis
- The rapid growth of online pharmaceutical channels has led to a dual-channel system where participants can sell through both online and offline methods, necessitating an exploration of their interactions and conflicts.
- This study utilizes a susceptible-infected-susceptible epidemic model to analyze the dynamics between these channels, revealing that increased influence rates in offline, online, and cross transmissions positively boost sales and customer conversion.
- The paper concludes with numerical analyses and managerial insights aimed at enhancing coordination and success in the dual-channel pharmaceutical supply chain.
[MIME-Mitosis instead of meiosis and its application in crop apomixis].
Sheng Wu Gong Cheng Xue Bao
April 2020
Article Synopsis
- Apomixis is important for heterosis fixation and artificial apomixis is a key focus in current research.
- Mitosis instead of meiosis (MIME) creates diploid gametes that match the mother's genetic makeup, crucial for artificial apomixis.
- This paper reviews MIME's occurrence, its applications in crop apomixis, and addresses challenges to help broaden its use in agriculture.
Article Synopsis
- Fine needle diathermy (FND) is effective in destroying harmful corneal blood and lymphatic vessels, but its potential to cause rebound neovascularization is unclear.
- In a study with female BALB/c mice, FND was combined with VEGF blockade or used alone to assess the effects on corneal blood and lymphatic vessels.
- Results showed that while FND alone reduced (lymph)angiogenesis initially, it led to rebound effects; however, combining it with VEGF TrapRR significantly improved outcomes by preventing these rebound effects and better regressing unwanted vessels.
Article Synopsis
- A study monitoring Walker moths in Luohe, China from 1980 to 2016 found a significant increase in annual average temperatures by about 0.298°C every decade.* -
- Higher temperatures in April and May led to earlier breeding cycles, resulting in more females reaching sexual maturity and causing an increase in the local first-generation moth population since 2006.* -
- The growth in moth populations has been linked to rising temperatures resulting in increased corn damage since 2007, indicating that climate warming may disrupt migratory patterns and negatively affect crop production.*
Article Synopsis
- In the last decade, new lamellar keratoplasty techniques like DALK, DSAEK, and DMEK have significantly improved corneal transplant outcomes by reducing endothelial graft rejection risk.
- While these modern methods address rejection issues in low-risk cases, they still face challenges with immune reactions and are not suitable for all patients, especially those in high-risk situations.
- This review will cover various keratoplasty techniques, their indications, complications, and outcomes, with a focus on endothelial graft rejection and future developments in preventing corneal allograft rejection.
Article Synopsis
- * YFTL treatment resulted in higher apoptosis rates in tumors and influenced several pathways, particularly Akt and MAPKs, suggesting a mechanism for tumor cell death and decreased tumor aggressiveness.
- * Additionally, YFTL reduced key proteins involved in tumor progression and showed immunomodulatory effects that improved the immune response in the tumor-bearing mice, indicating its potential as a cancer therapy.
Article Synopsis
- - The study investigates the effects of transcranial direct current stimulation (tDCS) on the thalamocortical network in individuals who experienced 24 hours of sleep deprivation (SD), aiming to understand the neural mechanisms behind the improvements in alertness and cognitive processing following tDCS treatment.
- - Using resting-state functional magnetic resonance imaging (fMRI), researchers found that tDCS significantly enhanced functional connectivity between the thalamus and other brain regions compared to a sham stimulation.
- - Results indicated that tDCS improved not just the connectivity, but also the overall efficiency of thalamic networks, potentially explaining previous findings of cognitive performance boosts after tDCS application.
Article Synopsis
- The study aimed to resolve discrepancies in aluminum measurements in reference substances by examining different pretreatment methods.
- Various pretreatment techniques, including wet digestion with nitric acid, microwave digestion with hydrogen fluoride, and dry ashing at various temperatures, were evaluated for their effectiveness in determining aluminum content using plasma emission spectrometry.
- Results indicated that using microwave digestion with hydrogen fluoride and higher temperature dry ashing (800-950 ℃) yielded accurate measurements, while other methods did not meet certification values for aluminum in reference substances.