Research on optimal allocation of water and land resources in the Yiluo River Basin, China.

The allocation of water and land resources (WLRs) has adhered to a system where they "serve as boundaries for each other," posing challenges in satisfying the exacting management requirements for these resources in the contemporary era. In line with precise predictions of the future WLRs, the optimal allocation framework of WLRs was constructed to obtain the rational configuration scheme. The prediction results showed that the imbalance between supply and demand of WLRs will intensify in the Yiluo River Basin.

HMIL: Hierarchical Multi-Instance Learning for Fine-Grained Whole Slide Image Classification.

Fine-grained classification of whole slide images (WSIs) is essential in precision oncology, enabling precise cancer diagnosis and personalized treatment strategies. The core of this task involves distinguishing subtle morphological variations within the same broad category of gigapixel-resolution images, which presents a significant challenge. While the multi-instance learning (MIL) paradigm alleviates the computational burden of WSIs, existing MIL methods often overlook hierarchical label correlations, treating fine-grained classification as a flat multi-class classification task.

POUR-Net: A Population-Prior-Aided Over-Under-Representation Network for Low-Count PET Attenuation Map Generation.

Low-dose PET offers a valuable means of minimizing radiation exposure in PET imaging. However, the prevalent practice of employing additional CT scans for generating attenuation maps (μ-map) for PET attenuation correction significantly elevates radiation doses. To address this concern and further mitigate radiation exposure in low-dose PET exams, we propose an innovative Population-prior-aided Over-Under-Representation Network (POUR-Net) that aims for high-quality attenuation map generation from low-dose PET.

The flavonoid-sensing regulator AefR is involved in modulating quorum sensing through repressing the MexEF-OprN efflux pump in .

Flavonoids, a major component of plant root exudates, play a crucial role in mediating plant-microbe interactions. However, the mechanisms by which flavonoids are perceived and trigger downstream signaling events in microbes remain largely unknown. In this study, we characterized AefR, a flavonoid-sensing transcriptional regulator from 2P24, a plant growth-promoting rhizobacterium (PGPR) known for its biocontrol properties.

Microplastics in the third pole of the world: Abundance and ecological risk assessment.

Microplastics (MPs) pose a threat to the Tibetan Plateau's ecosystems. Previous studies focused mainly on lakes and specific river segments, lacking a basin-wide analysis. This study systematically examined the abundance, composition, and spatial distribution of MPs in surface waters, sediments, and sewage treatment plant tailwater in the Yarlung Zangbo River Basin (water samples through 100 µm sieve).

Targeting efflux pumps prevents the multi-step evolution of high-level resistance to fluoroquinolone in .

Antibiotic resistance is emerging as a significant global health crisis, necessitating the urgent development of novel antibiotics or alternative therapies. Although it is recognized that bacteria require multiple mutations to develop resistance levels exceeding the mutant prevention concentration, the specific mutation combinations conferring high resistance have been largely undefined. Here, we investigated the multi-step evolution of fluoroquinolone resistance in through experimental evolution and whole-genome sequencing coupled with proteomic approaches.

Dietary simple sugar intake, metabolic indicators, markers of inflammation, and injury among semi-professional football players.

Background: Dietary sugar intake has been implicated in the development of metabolic dysfunction, chronic inflammation, and immune dysfunction, contributing to the pathogenesis of various diseases. This study aimed to investigate the associations between dietary total simple sugar intake and glycemic markers, lipid profile, serum levels of high-sensitivity C-reactive protein (hs-CRP), and adenosine deaminase activity (ADA), among semi-professional football players.

Methods: A cross-sectional study was conducted among 108 semi-professional football players.

Pseudocapsule thickness is positively associated with prognosis in patients with clear cell renal cell carcinoma.

Background: Tumour pseudocapsule shows plasticity, whose representative indicator- pseudocapsule thickness- was little studied in clear cell renal cell carcinoma (ccRCC).

Methods: We enrolled 1037 ccRCC patients who underwent surgery between 2006 and 2013 at our institution. The patients did not receive therapy before surgery and were confirmed to have a pathological pseudocapsule.

Increasing rice yield with low ammonia volatilization by combined application of controlled-release blended fertilizer and densification.

Controlled-release blended fertilizer (CRBF) and densification can increase rice yield and nitrogen (N) efficiency. However, the effects of CRBF combined with densification on rice yield, N absorption, economic benefits of fertilization, and ammonia volatilization loss remain unclear. A 2-year field experiment was conducted using five treatments: no N (control, CK), conventional N application (farmer's fertilization practice, FFP), optimal N application (OPT), single basal application of CRBF (CRBF), and CRBF combined with densification (CRFDP).

Research trends in the use of nanobodies for cancer therapy.

Although there are many challenges in using nanobodies for treating various complex tumor diseases, including rapid renal clearance and the complex blood-brain barrier environment, nanobodies have shown great potential due to their high antigen affinity, excellent tumor penetration ability, and favorable safety profile. Since the discovery of the variable domain (VHH) of camelid heavy-chain antibodies in 1993, nanobodies have been progressively applied to various cancer therapy platforms, such as antagonistic drugs and targeting agents for effector domains. In recent years, several nanobody-based drugs, including Caplacizumab, KN-035, and Ozoralizumab, have been approved for clinical use.

Deposited dead algae influence the microbial communities and functional potentials on the surface sediment in eutrophic shallow lakes.

Dead algae deposition will change the nutrient transformation on the sediment-water interface. However, the key factors that drive nutrient turnover, particularly the influence of sediment microbiota, remain poorly understood. As a result, this study conducted an 80-day simulated incubation to investigate the effect of different deposition of death algae on microbial communities and functional potentials in sediments.

Accuracy analysis of the digital occlusal relationship reconstruction workflow in patients with maxillofacial fractures: An in vitro retrospective cohort study.

Objective: To verify the accuracy of a digital workflow for occlusal relationship reduction in patients with maxillofacial fractures via cone beam computed tomograhy/ computerized tomography (CBCT/CT).

Methods: We collected CBCT/CT data and oral scan data from both general patients and fracture patients and established digital models. The differences between the oral scan model and the CBCT/CT digital model were compared.

TREM2 promotes the formation of a tumor-supportive microenvironment in hepatocellular carcinoma.

Background: Triggering receptor expressed on myeloid cells 2 (TREM2), a surface receptor predominantly expressed on myeloid cells, is a major hub gene in pathology-induced immune signaling. However, its function in hepatocellular carcinoma (HCC) remains controversial. This study aimed to evaluate the role of TREM2 in the tumor microenvironment in the context of HCC progression.

Spatiotemporal Variation Assessment and Improved Prediction Of Cyanobacteria Blooms in Lakes Using Improved Machine Learning Model Based on Multivariate Data.

Cyanobacterial blooms in shallow lakes pose a significant threat to aquatic ecosystems and public health worldwide, highlighting the urgent need for advanced predictive methodologies. As impounded lakes along the Eastern Route of the South-to-North Water Diversion Project, Lakes Hongze and Luoma play a key role in water resource management, making the prediction of cyanobacterial blooms in these lakes particularly important. To address this, satellite remote sensing data were utilized to analyze the spatiotemporal dynamics of cyanobacterial blooms in these lakes.

A Synergistic Effect of Remnant Cholesterol and C-Reactive Protein on Predicting the Severity of Coronary Artery Disease.

Background: Increased levels of remnant cholesterol (RC) and inflammation are linked to higher risks of atherosclerotic cardiovascular disease. Whether a combination of C-reactive protein (CRP) and RC improves the predictive ability for evaluating the severity of coronary artery lesions remains unknown.

Methods: A total of 1675 patients with coronary artery disease were stratified according to the Synergy Between Percutaneous Coronary Intervention (SYNTAX) score (SYNTAX score ≤22 versus SYNTAX score >22).

Molecular Hydride Superconductor BiH with up to 91 K at 170 GPa.

In pursuit of high- hydride superconductors, the molecular hydrides have attracted less attention because the hydrogen quasimolecules are usually inactive for superconductivity. Here, we report on the successful synthesis of a novel bismuth hydride superconductor 2/-BiH at pressures around 170-180 GPa. Its structure comprises bismuth atoms and elongated hydrogen molecules with a H-H bond length of 0.

Dynamic changes of leachates of aged plastic debris under different suspended sand concentrations and their toxicity.

Plastic pollution in aquatic environments poses significant ecological risks, particularly through released leachates. While traditional or non-biodegradable plastics (non-BPs) are well-studied, biodegradable plastics (BPs) have emerged as alternatives that are designed to degrade more rapidly within the environment. However, research on the ecological risks of the leachates from aged BPs in aquatic environments is scarce.

Deep Crotonylproteomics Analysis of High-Altitude Exposure Hearts in Mice.

The potential molecular mechanisms of short-term adaptation and long-term structural deteriorations in the cardiac structure in response to high altitude remain not fully understood. This study aims to investigate changes in the crotonylproteome in the hearts of mice exposed to high altitude at different time points. The hearts were obtained from mice living at the lowland and 3, 10, and 30 days after arriving at a plateau.

Manganese improves CD8 T cell recruitment via cGAS-STING in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths worldwide. Chemotherapy using cisplatin, a drug that damages deoxyribonucleic acid (DNA), is not very effective in treating HCC due to its side effects and drug resistance. Manganese (Mn), a trace element, has been shown to enhance immune responses, but its ability to improve cisplatin-induced antitumor immunity in HCC remains unclear.

Effects of reduced flow gradient on benthic biofilm communities' ecological network and community assembly.

The intensification of human activities has led to flow reduction and cut-off in most global rivers, seriously affecting riverine organisms and the biogeochemical processes. As key indicators of river ecosystems' structure and function, benthic biofilms play a critical role in driving primary production and material cycling in rivers. This research aimed to investigate the characteristics of microbial communities' complexity and stability during river flow reduction.

Long-term effects of dead algal deposition on sediment surfaces: Behavior of endogenous phosphorus release in sediments.

Algae blooms are frequently triggered owing to the improvements in aquatic trophic levels. The aggregated algae from these blooms are eventually dead and accumulate on sediment surfaces, impacting the microenvironment and phosphorus cycling in aquatic systems. However, research on the effects of naturally dead algal deposition on endogenous P release from sediments is lacking.

The clinical prospects and challenges of photothermal nanomaterials in myocardium recovery after myocardial infarction.

The high morbidity and mortality rates associated with myocardial infarction pose a serious threat to human health. Early diagnosis and appropriate treatment are crucial in saving the lives of patients. In recent years, nanomaterials-based technologies have played a significant role in developing new strategies for cardiac repair, particularly in the use of photothermal nanomaterials, which show great potential in treating myocardial infarction.

Distinct effects of flow intermittency on the benthic microbial diversity and their denitrification on different substrates.

Global climate change has significantly increased the duration of droughts in intermittent rivers, impacting benthic microbial-mediated biogeochemical processes. However, the response mechanisms of biofilms on different substrate types to alternating dry and wet conditions and their related ecosystem functions remain poorly understood. This study uses high-throughput sequencing and enzyme assays to investigate the impact of gradient drought stress on microbial diversity and functional changes of biofilm communities inhabiting on gravel, cobblestone, and sediment.

Photodynamic therapy compared with loop electrosurgical excision procedure in patients with cervical high-grade squamous intraepithelial lesion.

The study aimed to compare the effectiveness between Hiporfin-photodynamic therapy (PDT) and loop electrosurgical excision procedure (LEEP) in treating cervical high-grade squamous intraepithelial lesion (HSIL). We conducted a retrospective analysis of 104 women diagnosed with cervical HSIL at our hospital from April 2019 to July 2023. With 1:1 matched case-control, 52 cases received Hiporfin-PDT and 52 cases underwent LEEP.

The predictive value of the ARC-HBR criteria for in-hospital bleeding risk following percutaneous coronary intervention in patients with acute coronary syndrome.

Background: The Academic Research Consortium for High Bleeding Risk (ARC-HBR) criteria were proposed for predicting bleeding risk in patients undergoing percutaneous coronary intervention (PCI). However, there is a lack of research evaluating the risk of in-hospital bleeding following PCI for acute coronary syndrome (ACS) utilizing the ARC-HBR criteria.

Methods And Results: This study involved 1013 ACS patients who underwent PCI and dual antiplatelet therapy.